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タイトル: | Polymorphism of the Tryptophan Hydroxylase 2 (TPH2) Gene Is Associated with Chimpanzee Neuroticism. |
著者: | Hong, Kyung-Won Weiss, Alexander Morimura, Naruki https://orcid.org/0000-0002-9117-4828 (unconfirmed) Udono, Toshifumi Hayasaka, Ikuo Humle, Tatyana Murayama, Yuichi Ito, Shin'ichi Inoue-Murayama, Miho |
著者名の別形: | 村山, 美穂 |
発行日: | Jul-2011 |
出版者: | Public Library of Science |
誌名: | PloS one |
巻: | 6 |
号: | 7 |
論文番号: | e22144 |
抄録: | In the brain, serotonin production is controlled by tryptophan hydroxylase 2 (TPH2), a genotype. Previous studies found that mutations on the TPH2 locus in humans were associated with depression and studies of mice and studies of rhesus macaques have shown that the TPH2 locus was involved with aggressive behavior. We previously reported a functional single nucleotide polymorphism (SNP) in the form of an amino acid substitution, Q468R, in the chimpanzee TPH2 gene coding region. In the present study we tested whether this SNP was associated with neuroticism in captive and wild-born chimpanzees living in Japan and Guinea, respectively. Even after correcting for multiple tests (Bonferroni p = 0.05/6 = 0.008), Q468R was significantly related to higher neuroticism (β = 0.372, p = 0.005). This study is the first to identify a genotype linked to a personality trait in chimpanzees. In light of the prior studies on humans, mice, and rhesus macaques, these findings suggest that the relationship between neuroticism and TPH2 has deep phylogenetic roots. |
著作権等: | © 2011 Hong et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
URI: | http://hdl.handle.net/2433/143668 |
DOI(出版社版): | 10.1371/journal.pone.0022144 |
PubMed ID: | 21765945 |
出現コレクション: | 学術雑誌掲載論文等 |
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