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Title: Evolutionary dynamics of spliceosomal intron revealed by in silico analyses of the P-Type ATPase superfamily genes.
Authors: Oda, Toshiyuki
Ohniwa, Ryosuke L
Suzuki, Yuki  KAKEN_id
Denawa, Masatsugu
Kumeta, Masahiro  kyouindb  KAKEN_id
Okamura, Hideyuki
Takeyasu, Kunio
Author's alias: 小田, 俊之
Keywords: Spliceosomal intron
Introns-late theory
Introns-early theory
Simulation
Proto-splice site
P-Type ATPase
Issue Date: Apr-2011
Publisher: Springer Science+Business Media B.V.
Journal title: Molecular biology reports
Volume: 38
Issue: 4
Start page: 2285
End page: 2293
Abstract: It has been long debated whether spliceosomal introns originated in the common ancestor of eukaryotes and prokaryotes. In this study, we tested the possibility that extant introns were inherited from the common ancestor of eukaryotes and prokaryotes using in silico simulation. We first identified 21 intron positions that are shared among different families of the P-Type ATPase superfamily, some of which are known to have diverged before the separation of prokaryotes and eukaryotes. Theoretical estimates of the expected number of intron positions shared by different genes suggest that the introns at those 21 positions were inserted independently. There seems to be no intron that arose from before the diversification of the P-Type ATPase superfamily. Namely, the present introns were inserted after the separation of eukaryotes and prokaryotes.
Rights: The final publication is available at www.springerlink.com
This is not the published version. Please cite only the published version.
この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
URI: http://hdl.handle.net/2433/147052
DOI(Published Version): 10.1007/s11033-010-0360-3
PubMed ID: 21046256
Appears in Collections:Journal Articles

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