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タイトル: | Evolutionary dynamics of spliceosomal intron revealed by in silico analyses of the P-Type ATPase superfamily genes. |
著者: | Oda, Toshiyuki Ohniwa, Ryosuke L Suzuki, Yuki Denawa, Masatsugu Kumeta, Masahiro Okamura, Hideyuki Takeyasu, Kunio |
著者名の別形: | 小田, 俊之 |
キーワード: | Spliceosomal intron Introns-late theory Introns-early theory Simulation Proto-splice site P-Type ATPase |
発行日: | Apr-2011 |
出版者: | Springer Science+Business Media B.V. |
誌名: | Molecular biology reports |
巻: | 38 |
号: | 4 |
開始ページ: | 2285 |
終了ページ: | 2293 |
抄録: | It has been long debated whether spliceosomal introns originated in the common ancestor of eukaryotes and prokaryotes. In this study, we tested the possibility that extant introns were inherited from the common ancestor of eukaryotes and prokaryotes using in silico simulation. We first identified 21 intron positions that are shared among different families of the P-Type ATPase superfamily, some of which are known to have diverged before the separation of prokaryotes and eukaryotes. Theoretical estimates of the expected number of intron positions shared by different genes suggest that the introns at those 21 positions were inserted independently. There seems to be no intron that arose from before the diversification of the P-Type ATPase superfamily. Namely, the present introns were inserted after the separation of eukaryotes and prokaryotes. |
著作権等: | The final publication is available at www.springerlink.com This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/147052 |
DOI(出版社版): | 10.1007/s11033-010-0360-3 |
PubMed ID: | 21046256 |
出現コレクション: | 学術雑誌掲載論文等 |
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