ソラフェニブ投与中に心筋転移を来たした進行性腎細胞癌の1例

Abstract

We present a case of myocardial metastasis from renal cell carcinoma (RCC) during the treatment with sorafenib. A 63-year-oldmale, who hadund ergone right radical nephrectomy, receivedinterferon-alpha (IFN), interleukin (IL-2) and5-flurouracil (5-FU) for the treatment of lung andpleural metastases. However, since this metastasis showed progressive disease, we administered sorafenib. Nine months after the introduction of sorafenib, he complainedof dyspnea. Chest computedtomography andcard iac ultrasonography revealed a low density mass at the cardiac muscle of the left cardiac ventricle, suggesting myocardial metastasis of RCC. Molecular targetedtherapy achieveda longer survival in advancedRCC patients in comparison with the immunotherapy using cytokines. Therefore, in metastasis evaluation, some organs which have been regardedas rare sites shouldbe carefully evaluated.