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Title: Asymmetric Activation of the Primary Motor Cortex during Observation of a Mirror Reflection of a Hand.
Authors: Tominaga, Wataru
Matsubayashi, Jun  kyouindb  KAKEN_id
Furuya, Makiko
Matsuhashi, Masao  kyouindb  KAKEN_id  orcid (unconfirmed)
Mima, Tatsuya  KAKEN_id
Fukuyama, Hidenao  KAKEN_id
Mitani, Akira  kyouindb  KAKEN_id
Author's alias: 三谷, 章
Issue Date: Nov-2011
Publisher: Public library of science
Journal title: PloS one
Volume: 6
Issue: 11
Thesis number: e28226
Abstract: Mirror therapy is an effective technique for pain relief and motor function recovery. It has been demonstrated that magnetic 20-Hz activity is induced in the primary motor cortex (M1) after median nerve stimulation and that the amount of the stimulus-induced 20-Hz activity is decreased when the M1 is activated. In the present study, we investigated how the image or the mirror reflection of a hand holding a pencil modulates the stimulus-induced 20-Hz activity in the M1. Neuromagnetic brain activity was recorded from 13 healthy right-handed subjects while they were either viewing directly their hand holding a pencil or viewing a mirror reflection of their hand holding a pencil. The 20-Hz activity in the left or the right M1 was examined after the right or the left median nerve stimulation, respectively, and the suppression of the stimulus-induced 20-Hz in the M1 by viewing directly one hand holding a pencil or by viewing the mirror image of the hand holding a pencil was assumed to indicate the activation of the M1. The results indicated that the M1 innervating the dominant hand was suppressed either by viewing directly the dominant hand holding a pencil or by viewing the mirror image of the non-dominant hand holding a pencil. On the other hand, the M1 innervating the non-dominant hand was activated by viewing the mirror image of the dominant hand holding a pencil, but was not activated by viewing directly the non-dominant hand holding a pencil. The M1 innervating either the dominant or the non-dominant hand, however, was not activated by viewing the hand on the side ipsilateral to the M1 examined or the mirror image of the hand on the side contralateral to the M1 exaimined. Such activation of the M1 might induce some therapeutic effects of mirror therapy.
Rights: © 2011 Tominaga et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
DOI(Published Version): 10.1371/journal.pone.0028226
PubMed ID: 22140555
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