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Title: Identification of novel mammalian phospholipids containing threonine, aspartate, and glutamate as the base moiety.
Authors: Omori, Taketo
Honda, Ai
Mihara, Hisaaki
Kurihara, Tatsuo  kyouindb  KAKEN_id  orcid (unconfirmed)
Esaki, Nobuyoshi  KAKEN_id
Author's alias: 三原, 久明
栗原, 達夫
江崎, 信芳
Keywords: Aspartate
Carboxylate–phosphate anhydride
Issue Date: 1-Nov-2011
Publisher: Elsevier B.V.
Journal title: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
Volume: 879
Issue: 29
Start page: 3296
End page: 3302
Abstract: In this study, we showed the occurrence of phosphatidyl-L-threonine (PThr), phosphatidyl-L-aspartate (PAsp), and phosphatidyl-L-glutamate (PGlu) in rat brain. Analyses using an HPLC-ESI-MS and an amino acid analyzer showed the presence of L-threonine, L-aspartate, and L-glutamate in the acid-hydrolysates of phospholipids from porcine cerebrum, rat cerebrum, and rat liver. Results of ESI-MS/MS analyses with neutral loss scanning and product ion scanning suggest the presence of PThr-(18:0, 18:1), PThr-(18:0, 22:6), PAsp-(18:0, 18:1), PAsp-(18:0, 22:6), PGlu-(18:0, 18:1), and PGlu-(18:0, 22:6) in rat brain. This is the first study to identify 2 novel phospholipids, PAsp and PGlu, with a carboxylate-phosphate anhydride bond, in living organisms.
Rights: © 2011 Elsevier B.V.
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
DOI(Published Version): 10.1016/j.jchromb.2011.04.033
PubMed ID: 21601537
Appears in Collections:Journal Articles

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