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タイトル: | A role for mDia, a Rho-regulated actin nucleator, in tangential migration of interneuron precursors. |
著者: | Shinohara, Ryota Thumkeo, Dean Kamijo, Hiroshi Kaneko, Naoko Sawamoto, Kazunobu Watanabe, Keisuke Takebayashi, Hirohide Kiyonari, Hiroshi Ishizaki, Toshimasa Furuyashiki, Tomoyuki Narumiya, Shuh |
著者名の別形: | 篠原, 亮太 古屋敷, 智之 成宮, 周 |
発行日: | 15-Jan-2012 |
出版者: | Nature Publishing Group |
引用: | Shinohara R, Thumkeo D, Kamijo H, Kaneko N, Sawamoto K, Watanabe K, Takebayashi H, Kiyonari H, Ishizaki T, Furuyashiki T, Narumiya S. A role for mDia, a Rho-regulated actin nucleator, in tangential migration of interneuron precursors. Nat Neurosci. 2012 Jan 15. doi: 10.1038/nn.3020. |
誌名: | Nature neuroscience |
巻: | 15 |
号: | 3 |
開始ページ: | 373 |
終了ページ: | 380 |
抄録: | In brain development, distinct types of migration, radial migration and tangential migration, are shown by excitatory and inhibitory neurons, respectively. Whether these two types of migration operate by similar cellular mechanisms remains unclear. We examined neuronal migration in mice deficient in mDia1 (also known as Diap1) and mDia3 (also known as Diap2), which encode the Rho-regulated actin nucleators mammalian diaphanous homolog 1 (mDia1) and mDia3. mDia deficiency impaired tangential migration of cortical and olfactory inhibitory interneurons, whereas radial migration and consequent layer formation of cortical excitatory neurons were unaffected. mDia-deficient neuroblasts exhibited reduced separation of the centrosome from the nucleus and retarded nuclear translocation. Concomitantly, anterograde F-actin movement and F-actin condensation at the rear, which occur during centrosomal and nuclear movement of wild-type cells, respectively, were impaired in mDia-deficient neuroblasts. Blockade of Rho-associated protein kinase (ROCK), which regulates myosin II, also impaired nuclear translocation. These results suggest that Rho signaling via mDia and ROCK critically regulates nuclear translocation through F-actin dynamics in tangential migration, whereas this mechanism is dispensable in radial migration. |
記述: | 神経細胞の配置メカニズムを解明-抑制性神経前駆細胞に特有の移動の機構が明らかに. 京都大学プレスリリース. 2012-1-16. |
著作権等: | © 2012 Nature America, Inc. 許諾条件により本文は2012-07-15に公開. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/152361 |
DOI(出版社版): | 10.1038/nn.3020 |
PubMed ID: | 22246438 |
関連リンク: | http://www.nature.com/neuro/journal/vaop/ncurrent/abs/nn.3020.html https://www.kyoto-u.ac.jp/static/ja/news_data/h/h1/news6/2011/120116_2.htm |
出現コレクション: | 学術雑誌掲載論文等 |
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