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Title: Efficient synthesis of aminomethylated azaindoles and corresponding pyrrole-fused derivatives by copper-catalyzed domino multicomponent coupling and cyclization
Authors: Hou, Zengye
Suzuki, Yamato
Oishi, Shinya  kyouindb  KAKEN_id
Fujii, Nobutaka  KAKEN_id
Ohno, Hiroaki  kyouindb  KAKEN_id
Author's alias: 藤井, 信孝
大野, 浩章
Keywords: CK2 inhibitor
Multicomponent reaction
Azaindole
Regioselective
Pyrrole-fused azaindole
Issue Date: Feb-2012
Publisher: Elsevier Ltd.
Journal title: Tetrahedron
Volume: 68
Issue: 6
Start page: 1695
End page: 1703
Abstract: Efficient methods for the synthesis of aminomethylated azaindole derivatives via domino copper-catalyzed multicomponent coupling and cyclization have been developed. Using various secondary amines and aldehydes, N-substituted 3-ethynyl-4-aminopyridine was converted to substituted azaindoles in moderate to excellent yields. By use of a 3, 4-diaminopyridine derivative bearing two alkynyl groups, the corresponding pyrrole-fused azaindoles were synthesized by controlled stepwise cyclization.
Rights: © 2011 Elsevier Ltd.
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
URI: http://hdl.handle.net/2433/153295
DOI(Published Version): 10.1016/j.tet.2011.12.059
Appears in Collections:Journal Articles

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