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| ファイル | 記述 | サイズ | フォーマット | |
|---|---|---|---|---|
| pnas.1120791109.pdf | 8.36 MB | Adobe PDF | 見る/開く |
| タイトル: | Nonimmunoglobulin target loci of activation-induced cytidine deaminase (AID) share unique features with immunoglobulin genes. |
| 著者: | Kato, Lucia Begum, Nasim A Burroughs, A Maxwell Doi, Tomomitsu Kawai, Jun Daub, Carsten O Kawaguchi, Takahisa Matsuda, Fumihiko   Hayashizaki, Yoshihide Honjo, Tasuku |
| 著者名の別形: | 加藤, ルシア ベガム, ナシム 土井, 知光 川口, 喬久 松田, 文彦 本庶, 佑 |
| 発行日: | 14-Feb-2012 |
| 出版者: | National Academy of Sciences |
| 誌名: | Proceedings of the National Academy of Sciences (PNAS) |
| 巻: | 109 |
| 号: | 7 |
| 開始ページ: | 2479 |
| 終了ページ: | 2484 |
| 抄録: | Activation-induced cytidine deaminase (AID) is required for both somatic hypermutation and class-switch recombination in activated B cells. AID is also known to target nonimmunoglobulin genes and introduce mutations or chromosomal translocations, eventually causing tumors. To identify as-yet-unknown AID targets, we screened early AID-induced DNA breaks by using two independent genome-wide approaches. Along with known AID targets, this screen identified a set of unique genes (SNHG3, MALAT1, BCL7A, and CUX1) and confirmed that these loci accumulated mutations as frequently as Ig locus after AID activation. Moreover, these genes share three important characteristics with the Ig gene: translocations in tumors, repetitive sequences, and the epigenetic modification of chromatin by H3K4 trimethylation in the vicinity of cleavage sites. |
| 著作権等: | ©2012 by the National Academy of Sciences この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 This is not the published version. Please cite only the published version. |
| URI: | http://hdl.handle.net/2433/154776 |
| DOI(出版社版): | 10.1073/pnas.1120791109 |
| PubMed ID: | 22308462 |
| 出現コレクション: | 学術雑誌掲載論文等 |
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