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タイトル: | Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels |
著者: | Harada, Hiroshi https://orcid.org/0000-0001-7507-3173 (unconfirmed) Inoue, Masahiro Itasaka, Satoshi Hirota, Kiichi Morinibu, Akiyo Shinomiya, Kazumi Zeng, Lihua Ou, Guangfei Zhu, Yuxi Yoshimura, Michio McKenna, W. Gillies Muschel, Ruth J. Hiraoka, Masahiro |
著者名の別形: | 原田, 浩 |
キーワード: | Biological sciences Cancer Medical research Molecular biology |
発行日: | 17-Apr-2012 |
出版者: | Nature Publishing Group |
誌名: | Nature Communications |
巻: | 3 |
開始ページ: | 1 |
終了ページ: | 10 |
論文番号: | 783 |
抄録: | Tumour recurrence frequently occurs after radiotherapy, but the characteristics, intratumoural localization and post-irradiation behaviour of radioresistant cancer cells remain largely unknown. Here we develop a sophisticated strategy to track the post-irradiation fate of the cells, which exist in perinecrotic regions at the time of radiation. Although the perinecrotic tumour cells are originally hypoxia-inducible factor 1 (HIF-1)-negative, they acquire HIF-1 activity after surviving radiation, which triggers their translocation towards tumour blood vessels. HIF-1 inhibitors suppress the translocation and decrease the incidence of post-irradiation tumour recurrence. For the first time, our data unveil the HIF-1-dependent cellular dynamics during post-irradiation tumour recurrence and provide a rational basis for targeting HIF-1 after radiation therapy. |
記述: | 放射線治療後のがんの再発メカニズムの解明. 2012-4-18. |
著作権等: | © 2012 Nature Publishing Group This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ |
URI: | http://hdl.handle.net/2433/155045 |
DOI(出版社版): | 10.1038/ncomms1786 |
PubMed ID: | 22510688 |
関連リンク: | http://www.kyoto-u.ac.jp/ja/news_data/h/h1/news6/2012/120418_1.htm |
出現コレクション: | 学術雑誌掲載論文等 |
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