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Title: A novel silk-like shell matrix gene is expressed in the mantle edge of the Pacific oyster prior to shell regeneration.
Authors: Takahashi, Jun
Takagi, Masaya
Okihana, Yumiko
Takeo, Kei
Ueda, Takahisa
Touhata, Ken
Maegawa, Shingo  kyouindb  KAKEN_id
Toyohara, Haruhiko  kyouindb  KAKEN_id
Author's alias: 豊原, 治彦
Keywords: Biomineralization
Pacific oyster
Spider-silk protein
Issue Date: 10-May-2012
Publisher: Elsevier B.V.
Journal title: Gene
Volume: 499
Issue: 1
Start page: 130
End page: 134
Abstract: During shell formation, little is known about the functions of organic matrices, especially about the biomineralization of shell prismatic layer. We identified a novel gene, shelk2, from the Pacific oyster presumed to be involved in the shell biosynthesis. The Pacific oyster has multiple copies of shelk2. Shelk2 mRNA is specifically expressed on the mantle edge and is induced during shell regeneration, thereby suggesting that Shelk2 is involved in shell biosynthesis. To our surprise, the database search revealed that it encodes a spider silk-like alanine-rich protein. Interestingly, most of the Shelk2 primary structure is composed of two kinds of poly-alanine motifs-GXNA(n)(S) and GSA(n)(S)-where X denotes Gln, Arg or no amino acid. Occurrence of common motifs of Shelk2 and spider silk led us to the assumption that shell and silk are constructed under similar strategies despite of their living environments.
Rights: © 2011 Elsevier B.V.
This is not the published version. Please cite only the published version.
DOI(Published Version): 10.1016/j.gene.2011.11.057
PubMed ID: 22197657
Appears in Collections:Journal Articles

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