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ファイル | 記述 | サイズ | フォーマット | |
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j.celrep.2012.03.001.pdf | 1.33 MB | Adobe PDF | 見る/開く |
タイトル: | Rhythmic Nucleotide Synthesis in the Liver: Temporal Segregation of Metabolites |
著者: | Fustin, Jean-Michel https://orcid.org/0000-0002-6200-6075 (unconfirmed) Doi, Masao https://orcid.org/0000-0001-6264-9217 (unconfirmed) Yamada, Hiroyuki Komatsu, Rie Shimba, Shigeki Okamura, Hitoshi |
キーワード: | circadian metabolome purine pyrimidine nucleotide synthesis |
発行日: | Apr-2012 |
出版者: | Elsevier BV |
誌名: | Cell Reports |
巻: | 1 |
号: | 4 |
開始ページ: | 341 |
終了ページ: | 349 |
抄録: | The synthesis of nucleotides in the body is centrally controlled by the liver, via salvage or de novo synthesis. We reveal a pervasive circadian influence on hepatic nucleotide metabolism, from rhythmic gene expression of rate-limiting enzymes to oscillating nucleotide metabolome in wild-type (WT) mice. Genetic disruption of the hepatic clock leads to aberrant expression of these enzymes, together with anomalous nucleotide rhythms, such as constant low levels of ATP with an excess in uric acid, the degradation product of purines. These results clearly demonstrate that the hepatic circadian clock orchestrates nucleotide synthesis and degradation. This circadian metabolome timetable, obtained using state-of-the-art capillary electrophoresis time-of-flight mass spectrometry, will guide further investigations in nucleotide metabolism-related disorders. |
著作権等: | © 2012 The Authors. Published by Elsevier Inc. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/156139 |
DOI(出版社版): | 10.1016/j.celrep.2012.03.001 |
PubMed ID: | 22832226 |
出現コレクション: | 学術雑誌掲載論文等 |
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