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Title: Bornavirus closely associates and segregates with host chromosomes to ensure persistent intranuclear infection.
Authors: Matsumoto, Yusuke
Hayashi, Yohei
Omori, Hiroko
Honda, Tomoyuki  KAKEN_id
Daito, Takuji
Horie, Masayuki  kyouindb  KAKEN_id  orcid (unconfirmed)
Ikuta, Kazuyoshi
Fujino, Kan
Nakamura, Shoko
Schneider, Urs
Chase, Geoffrey
Yoshimori, Tamotsu
Schwemmle, Martin
Tomonaga, Keizo  kyouindb  KAKEN_id
Author's alias: 朝長, 啓造
Issue Date: 17-May-2012
Publisher: Elsevier Inc.
Journal title: Cell host & microbe
Volume: 11
Issue: 5
Start page: 492
End page: 503
Abstract: Bornaviruses are nonsegmented negative-strand RNA viruses that establish a persistent infection in the nucleus and occasionally integrate a DNA genome copy into the host chromosomal DNA. However, how these viruses achieve intranuclear infection remains unclear. We show that Borna disease virus (BDV), a mammalian bornavirus, closely associates with the cellular chromosome to ensure intranuclear infection. BDV generates viral factories within the nucleus using host chromatin as a scaffold. In addition, the viral ribonucleoprotein (RNP) interacts directly with the host chromosome throughout the cell cycle, using core histones as a docking platform. HMGB1, a host chromatin-remodeling DNA architectural protein, is required to stabilize RNP on chromosomes and for efficient BDV RNA transcription in the nucleus. During metaphase, the association of RNP with mitotic chromosomes allows the viral RNA to segregate into daughter cells and ensure persistent infection. Thus, bornaviruses likely evolved a chromosome-dependent life cycle to achieve stable intranuclear infection.
Rights: © 2012 Elsevier Inc.
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
DOI(Published Version): 10.1016/j.chom.2012.04.009
PubMed ID: 22607802
Appears in Collections:Journal Articles

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