ダウンロード数: 209
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
j.chom.2012.04.009.pdf | 28.98 MB | Adobe PDF | 見る/開く |
タイトル: | Bornavirus closely associates and segregates with host chromosomes to ensure persistent intranuclear infection. |
著者: | Matsumoto, Yusuke Hayashi, Yohei Omori, Hiroko Honda, Tomoyuki Daito, Takuji Horie, Masayuki https://orcid.org/0000-0003-4682-7698 (unconfirmed) Ikuta, Kazuyoshi Fujino, Kan Nakamura, Shoko Schneider, Urs Chase, Geoffrey Yoshimori, Tamotsu Schwemmle, Martin Tomonaga, Keizo https://orcid.org/0000-0003-0405-7103 (unconfirmed) |
著者名の別形: | 朝長, 啓造 |
発行日: | 17-May-2012 |
出版者: | Elsevier Inc. |
誌名: | Cell host & microbe |
巻: | 11 |
号: | 5 |
開始ページ: | 492 |
終了ページ: | 503 |
抄録: | Bornaviruses are nonsegmented negative-strand RNA viruses that establish a persistent infection in the nucleus and occasionally integrate a DNA genome copy into the host chromosomal DNA. However, how these viruses achieve intranuclear infection remains unclear. We show that Borna disease virus (BDV), a mammalian bornavirus, closely associates with the cellular chromosome to ensure intranuclear infection. BDV generates viral factories within the nucleus using host chromatin as a scaffold. In addition, the viral ribonucleoprotein (RNP) interacts directly with the host chromosome throughout the cell cycle, using core histones as a docking platform. HMGB1, a host chromatin-remodeling DNA architectural protein, is required to stabilize RNP on chromosomes and for efficient BDV RNA transcription in the nucleus. During metaphase, the association of RNP with mitotic chromosomes allows the viral RNA to segregate into daughter cells and ensure persistent infection. Thus, bornaviruses likely evolved a chromosome-dependent life cycle to achieve stable intranuclear infection. |
著作権等: | © 2012 Elsevier Inc. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/156163 |
DOI(出版社版): | 10.1016/j.chom.2012.04.009 |
PubMed ID: | 22607802 |
出現コレクション: | 学術雑誌掲載論文等 |
このリポジトリに保管されているアイテムはすべて著作権により保護されています。