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j.chom.2012.04.009.pdf | 28.98 MB | Adobe PDF | View/Open |
Title: | Bornavirus closely associates and segregates with host chromosomes to ensure persistent intranuclear infection. |
Authors: | Matsumoto, Yusuke Hayashi, Yohei Omori, Hiroko Honda, Tomoyuki ![]() Daito, Takuji Horie, Masayuki ![]() ![]() Ikuta, Kazuyoshi Fujino, Kan Nakamura, Shoko Schneider, Urs Chase, Geoffrey Yoshimori, Tamotsu Schwemmle, Martin Tomonaga, Keizo ![]() ![]() ![]() |
Author's alias: | 朝長, 啓造 |
Issue Date: | 17-May-2012 |
Publisher: | Elsevier Inc. |
Journal title: | Cell host & microbe |
Volume: | 11 |
Issue: | 5 |
Start page: | 492 |
End page: | 503 |
Abstract: | Bornaviruses are nonsegmented negative-strand RNA viruses that establish a persistent infection in the nucleus and occasionally integrate a DNA genome copy into the host chromosomal DNA. However, how these viruses achieve intranuclear infection remains unclear. We show that Borna disease virus (BDV), a mammalian bornavirus, closely associates with the cellular chromosome to ensure intranuclear infection. BDV generates viral factories within the nucleus using host chromatin as a scaffold. In addition, the viral ribonucleoprotein (RNP) interacts directly with the host chromosome throughout the cell cycle, using core histones as a docking platform. HMGB1, a host chromatin-remodeling DNA architectural protein, is required to stabilize RNP on chromosomes and for efficient BDV RNA transcription in the nucleus. During metaphase, the association of RNP with mitotic chromosomes allows the viral RNA to segregate into daughter cells and ensure persistent infection. Thus, bornaviruses likely evolved a chromosome-dependent life cycle to achieve stable intranuclear infection. |
Rights: | © 2012 Elsevier Inc. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/156163 |
DOI(Published Version): | 10.1016/j.chom.2012.04.009 |
PubMed ID: | 22607802 |
Appears in Collections: | Journal Articles |

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