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Title: Pretransplant serum ferritin and C-reactive protein as predictive factors for early bacterial infection after allogeneic hematopoietic cell transplantation.
Authors: Kanda, J  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-6704-3633 (unconfirmed)
Mizumoto, C
Ichinohe, T
Kawabata, H  KAKEN_id
Saito, T
Yamashita, K  kyouindb  KAKEN_id
Kondo, T  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-8959-6271 (unconfirmed)
Takakura, S  kyouindb  KAKEN_id
Ichiyama, S  kyouindb  KAKEN_id
Uchiyama, T
Ishikawa, T
Author's alias: 諫田, 淳也
Keywords: antibacterial prophylaxis
fluoroquinolone
bacterial infection
allogeneic hematopoietic cell transplantation
Issue Date: Feb-2011
Publisher: Nature Publishing Group
Journal title: Bone marrow transplantation
Volume: 46
Issue: 2
Start page: 208
End page: 216
Abstract: Although fluoroquinolones or other antibiotics are commonly used to prevent bacterial infections after hematopoietic cell transplantation (HCT), because of the growing presence of multidrug-resistant microorganisms, it is important to identify patients who are more likely to benefit from antibacterial prophylaxis. To evaluate risk factors for early bacterial infection after allogeneic HCT, we retrospectively analyzed clinical data for 112 consecutive adult patients with hematological malignancies who received transplants without any antibacterial prophylaxis. The cumulative incidence of bacterial infection at 30 days after transplantation was 16%. Among various pre-transplant factors, only high serum ferritin (>700 ng/mL, 47 patients) and high C-reactive protein (CRP) (>0.3 mg/dL, 28 patients) levels were significantly associated with the development of bacterial infection in a multivariate analysis (hazard ratio (95% confidence interval): ferritin, 4.00 (1.32-12.17); CRP, 3.64 (1.44-9.20)). In addition, septic shock and sepsis with organ failure were exclusively observed in patients who had high ferritin and/or high CRP levels. These results suggest that pretransplant serum ferritin and CRP levels can be useful markers for predicting the risk of early bacterial infection after allogeneic HCT. It may be prudent to limit antibacterial prophylaxis to patients with predefined risk factors to ensure the safety of HCT with the use of fewer antibiotics.
Rights: © 2011 Nature Publishing Group, a division of Macmillan Publishers Limited.
この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。This is not the published version. Please cite only the published version.
URI: http://hdl.handle.net/2433/156403
DOI(Published Version): 10.1038/bmt.2010.108
PubMed ID: 20436524
Appears in Collections:Journal Articles

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