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dc.contributor.authorNagatomo, Fumikoja
dc.contributor.authorFujino, Hidemija
dc.contributor.authorKondo, Hiroyoja
dc.contributor.authorKouzaki, Motokija
dc.contributor.authorGu, Ningja
dc.contributor.authorTakeda, Isaoja
dc.contributor.authorTsuda, Kinsukeja
dc.contributor.authorIshihara, Akihikoja
dc.contributor.alternative石原, 昭彦ja
dc.description.abstractSkeletal muscles in animals with metabolic syndrome exhibit reduced oxidative capacity. We investigated the effects of running exercise on fiber characteristics, oxidative capacity, and mRNA levels in the soleus muscles of rats with metabolic syndrome [SHR/NDmcr-cp (cp/cp); CP]. We divided 5-week-old CP rats into non-exercise (CP) and exercise (CP-Ex) groups. Wistar-Kyoto rats (WKY) were used as the control group. CP-Ex rats were permitted voluntary exercise on running wheels for 10 weeks. Triglyceride levels were higher and adiponectin levels lower in the CP and CP-Ex groups than in the WKY group. However, triglyceride levels were lower and adiponectin levels higher in the CP-Ex group than in the CP group. The soleus muscles in CP-Ex rats contained only high-oxidative type I fibers, whereas those in WKY and CP rats contained type I, IIA, and IIC fibers. Muscle succinate dehydrogenase (SDH) activity was higher in the CP-Ex group than in the CP group; there was no difference in SDH activity between the WKY and CP-Ex groups. Muscle proliferator-activated receptor γ coactivator-1α (PGC-1α) mRNA levels were higher in the CP-Ex group than in the CP group; there was no difference in PGC-1α mRNA levels between the WKY and CP-Ex groups. In CP-Ex rats, longer running distance was associated with increased muscle SDH activity and PGC-1α mRNA levels. We concluded that running exercise restored decreased muscle oxidative capacity and PGC-1α mRNA levels and improved hypertriglyceridemia in rats with metabolic syndrome.ja
dc.publisherThe Physiological Society of Japan and Springerja
dc.rightsThe final publication is available at www.springerlink.comja
dc.rightsThis is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。ja
dc.subjectMuscle fiber typeja
dc.subjectSuccinate dehydrogenase activityja
dc.titleThe effects of running exercise on oxidative capacity and PGC-1α mRNA levels in the soleus muscle of rats with metabolic syndrome.ja
dc.type.niitypeJournal Articleja
dc.identifier.jtitleThe journal of physiological sciences : JPSja
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