|Title:||Temporary blood pressure drop after bevacizumab administration is associated with clinical course of advanced colorectal cancer.|
|Authors:||Kanai, M |
|Author's alias:||金井, 雅史|
|Publisher:||Nature Publishing Group|
|Journal title:||British journal of cancer|
|Abstract:||[Background]: A blood pressure drop after bevacizumab administration and its clinical significance have not been previously reported. [Methods]: Blood pressure data at 0, 90, and 180 min after a total of 162 bevacizumab administrations in 81 advanced colorectal cancer patients were retrospectively investigated. [Results]: Twenty-five patients (30%) demonstrated an average temporary drop of 20 mm Hg or more in systolic blood pressure. We classified these 25 patients as group A and the others as group B. Median time-to-treatment failure (TTF) was significantly longer in group A than in group B (291 vs 162 days; P=0.02). Furthermore, the proportion of patients who required intervention with antihypertensive drugs during bevacizumab treatment was significantly higher in group A than in group B (36% vs 4%; P<0.01). [Conclusion]: This study suggests that a temporary blood pressure drop after bevacizumab administration could be a predictive marker for bevacizumab treatment.|
|Rights:||© 2012 Cancer Research UK|
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|Appears in Collections:||Journal Articles |
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