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タイトル: | Temporary blood pressure drop after bevacizumab administration is associated with clinical course of advanced colorectal cancer. |
著者: | Kanai, M Ishiguro, H Mori, Y Kitano, T Nishimura, T Matsumoto, S https://orcid.org/0000-0001-6453-7489 (unconfirmed) Yanagihara, K Chiba, T Toi, M https://orcid.org/0000-0003-1488-9958 (unconfirmed) |
著者名の別形: | 金井, 雅史 |
キーワード: | bevacizumab blood pressure hypotension predictive marker |
発行日: | 22-Nov-2011 |
出版者: | Nature Publishing Group |
誌名: | British journal of cancer |
巻: | 105 |
号: | 11 |
開始ページ: | 1693 |
終了ページ: | 1696 |
抄録: | [Background]: A blood pressure drop after bevacizumab administration and its clinical significance have not been previously reported. [Methods]: Blood pressure data at 0, 90, and 180 min after a total of 162 bevacizumab administrations in 81 advanced colorectal cancer patients were retrospectively investigated. [Results]: Twenty-five patients (30%) demonstrated an average temporary drop of 20 mm Hg or more in systolic blood pressure. We classified these 25 patients as group A and the others as group B. Median time-to-treatment failure (TTF) was significantly longer in group A than in group B (291 vs 162 days; P=0.02). Furthermore, the proportion of patients who required intervention with antihypertensive drugs during bevacizumab treatment was significantly higher in group A than in group B (36% vs 4%; P<0.01). [Conclusion]: This study suggests that a temporary blood pressure drop after bevacizumab administration could be a predictive marker for bevacizumab treatment. |
著作権等: | © 2012 Cancer Research UK この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 This is not the published version. Please cite only the published version. |
URI: | http://hdl.handle.net/2433/158037 |
DOI(出版社版): | 10.1038/bjc.2011.398 |
PubMed ID: | 22033274 |
出現コレクション: | 学術雑誌掲載論文等 |
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