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Title: Temporary blood pressure drop after bevacizumab administration is associated with clinical course of advanced colorectal cancer.
Authors: Kanai, M  kyouindb  KAKEN_id
Ishiguro, H  kyouindb  KAKEN_id
Mori, Y  kyouindb  KAKEN_id
Kitano, T  kyouindb  KAKEN_id
Nishimura, T
Matsumoto, S  kyouindb  KAKEN_id
Yanagihara, K
Chiba, T  kyouindb  KAKEN_id
Toi, M  kyouindb  KAKEN_id
Author's alias: 金井, 雅史
Keywords: bevacizumab
blood pressure
hypotension
predictive marker
Issue Date: 22-Nov-2011
Publisher: Nature Publishing Group
Journal title: British journal of cancer
Volume: 105
Issue: 11
Start page: 1693
End page: 1696
Abstract: [Background]: A blood pressure drop after bevacizumab administration and its clinical significance have not been previously reported. [Methods]: Blood pressure data at 0, 90, and 180 min after a total of 162 bevacizumab administrations in 81 advanced colorectal cancer patients were retrospectively investigated. [Results]: Twenty-five patients (30%) demonstrated an average temporary drop of 20 mm Hg or more in systolic blood pressure. We classified these 25 patients as group A and the others as group B. Median time-to-treatment failure (TTF) was significantly longer in group A than in group B (291 vs 162 days; P=0.02). Furthermore, the proportion of patients who required intervention with antihypertensive drugs during bevacizumab treatment was significantly higher in group A than in group B (36% vs 4%; P<0.01). [Conclusion]: This study suggests that a temporary blood pressure drop after bevacizumab administration could be a predictive marker for bevacizumab treatment.
Rights: © 2012 Cancer Research UK
この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。This is not the published version. Please cite only the published version.
URI: http://hdl.handle.net/2433/158037
DOI(Published Version): 10.1038/bjc.2011.398
PubMed ID: 22033274
Appears in Collections:Journal Articles

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