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j.cllc.2011.11.001.pdf | 345.13 kB | Adobe PDF | 見る/開く |
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dc.contributor.author | Togashi, Yosuke | en |
dc.contributor.author | Masago, Katsuhiro | en |
dc.contributor.author | Handa, Tomohiro | en |
dc.contributor.author | Tanizawa, Kiminobu | en |
dc.contributor.author | Okuda, Chiyuki | en |
dc.contributor.author | Sakamori, Yuichi | en |
dc.contributor.author | Nagai, Hiroki | en |
dc.contributor.author | Kim, Young Hak | en |
dc.contributor.author | Mishima, Michiaki | en |
dc.contributor.alternative | 冨樫, 庸介 | ja |
dc.date.accessioned | 2012-07-11T07:07:30Z | - |
dc.date.available | 2012-07-11T07:07:30Z | - |
dc.date.issued | 2012-07 | - |
dc.identifier.issn | 1525-7304 | - |
dc.identifier.uri | http://hdl.handle.net/2433/158292 | - |
dc.description.abstract | [Background] In Japan, iatrogenic acute exacerbation of interstitial lung disease (ILD) is a serious complication in patients with lung cancer and simultaneous ILD. Results of some reports suggest that patients with ILD and small-cell lung cancer (SCLC) might benefit from chemotherapy, but the influence of ILD on prognosis is unclear. [Patients and Methods] Retrospective study of patients with SCLC with or without ILD. Between April 2006 and March 2011, 122 patients with SCLC who were receiving platinum-based combination chemotherapy participated. [Results] Twenty-eight patients (23.0%) had ILD at diagnosis. Pneumonitis associated with chemotherapy, including acute exacerbation–ILD was significantly increased in patients with preexisting ILD (8/28 vs. 2/94; P = .0001). In patients receiving chemotherapy alone, response rates and median progression-free survival of first-line chemotherapy in patients with or without preexisting ILD was not significantly different (P = .26; 20/26 vs. 52/60 and P = .089; 4.4 months vs. 5.4 months, respectively). The median overall survival of all patients was 15.5 months, but those without preexisting ILD survived significantly longer (P = .0010; 17.8 months vs. 10.7 months). Multivariate analysis revealed that performance status of 0 or 1 (hazard ratio [HR] 0.19 [95% confidence interval {CI}, 0.10-0.37]; P < .0001) limited disease (HR 0.42 [95% CI, 0.23-0.73]; P = .0017), and no preexisting ILD (HR 0.36 [95% CI, 0.19-0.69]; P = .0027) were significantly associated with longer overall survival. [Conclusion]Patients with SCLC and ILD might benefit from chemotherapy, but preexisting ILD is an independent prognostic factor for poorer survival. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier Inc. | en |
dc.rights | © 2012 Elsevier Inc. | en |
dc.rights | This is not the published version. Please cite only the published version. | en |
dc.rights | この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | ja |
dc.subject | Acute exacerbation | en |
dc.subject | Chemotherapy | en |
dc.subject | Idiopathic pulmonary fibrosis | en |
dc.subject | Interstitial lung disease | en |
dc.subject | Small-cell lung cancer | en |
dc.title | Prognostic significance of preexisting interstitial lung disease in Japanese patients with small-cell lung cancer. | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.ncid | AA11973261 | - |
dc.identifier.jtitle | Clinical lung cancer | en |
dc.identifier.volume | 13 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 304 | - |
dc.identifier.epage | 311 | - |
dc.relation.doi | 10.1016/j.cllc.2011.11.001 | - |
dc.textversion | author | - |
dc.identifier.pmid | 22169479 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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