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dc.contributor.author | Kakizawa, Sho | en |
dc.contributor.author | Yamazawa, Toshiko | en |
dc.contributor.author | Chen, Yili | en |
dc.contributor.author | Ito, Akihiro | en |
dc.contributor.author | Murayama, Takashi | en |
dc.contributor.author | Oyamada, Hideto | en |
dc.contributor.author | Kurebayashi, Nagomi | en |
dc.contributor.author | Sato, Osamu | en |
dc.contributor.author | Watanabe, Masahiko | en |
dc.contributor.author | Mori, Nozomu | en |
dc.contributor.author | Oguchi, Katsuji | en |
dc.contributor.author | Sakurai, Takashi | en |
dc.contributor.author | Takeshima, Hiroshi | en |
dc.contributor.author | Saito, Nobuhito | en |
dc.contributor.author | Iino, Masamitsu | en |
dc.contributor.alternative | 柿澤, 昌 | ja |
dc.date.accessioned | 2012-07-30T01:25:36Z | - |
dc.date.available | 2012-07-30T01:25:36Z | - |
dc.date.issued | 2012-01-18 | - |
dc.identifier.issn | 0261-4189 | - |
dc.identifier.uri | http://hdl.handle.net/2433/158743 | - |
dc.description.abstract | Mobilization of intracellular Ca(2+) stores regulates a multitude of cellular functions, but the role of intracellular Ca(2+) release via the ryanodine receptor (RyR) in the brain remains incompletely understood. We found that nitric oxide (NO) directly activates RyRs, which induce Ca(2+) release from intracellular stores of central neurons, and thereby promote prolonged Ca(2+) signalling in the brain. Reversible S-nitrosylation of type 1 RyR (RyR1) triggers this Ca(2+) release. NO-induced Ca(2+) release (NICR) is evoked by type 1 NO synthase-dependent NO production during neural firing, and is essential for cerebellar synaptic plasticity. NO production has also been implicated in pathological conditions including ischaemic brain injury, and our results suggest that NICR is involved in NO-induced neuronal cell death. These findings suggest that NICR via RyR1 plays a regulatory role in the physiological and pathophysiological functions of the brain. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | en |
dc.rights | © 2012 European Molecular Biology Organization | en |
dc.rights | This is not the published version. Please cite only the published version. | en |
dc.rights | この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | ja |
dc.subject | calcium | en |
dc.subject | nitric oxide | en |
dc.subject | ryanodine receptor | en |
dc.subject | synapse | en |
dc.subject.mesh | Animals | en |
dc.subject.mesh | Apoptosis/drug effects | en |
dc.subject.mesh | Calcium Signaling/physiology | en |
dc.subject.mesh | Cerebellum/cytology | en |
dc.subject.mesh | Cerebellum/physiology | en |
dc.subject.mesh | Cerebral Cortex/cytology | en |
dc.subject.mesh | Cerebral Cortex/physiology | en |
dc.subject.mesh | HEK293 Cells | en |
dc.subject.mesh | Humans | en |
dc.subject.mesh | Infarction, Middle Cerebral Artery/pathology | en |
dc.subject.mesh | Male | en |
dc.subject.mesh | Mice | en |
dc.subject.mesh | Mice, Inbred C57BL | en |
dc.subject.mesh | Mice, Knockout | en |
dc.subject.mesh | Microscopy, Fluorescence | en |
dc.subject.mesh | Nerve Tissue Proteins/physiology | en |
dc.subject.mesh | Neurons/physiology | en |
dc.subject.mesh | Nitric Oxide/physiology | en |
dc.subject.mesh | Nitric Oxide Synthase Type I/deficiency | en |
dc.subject.mesh | Nitric Oxide Synthase Type I/genetics | en |
dc.subject.mesh | Nitric Oxide Synthase Type I/physiology | en |
dc.subject.mesh | Patch-Clamp Techniques | en |
dc.subject.mesh | Recombinant Fusion Proteins/physiology | en |
dc.subject.mesh | Ryanodine Receptor Calcium Release Channel/biosynthesis | en |
dc.subject.mesh | Ryanodine Receptor Calcium Release Channel/deficiency | en |
dc.subject.mesh | Ryanodine Receptor Calcium Release Channel/genetics | en |
dc.subject.mesh | Ryanodine Receptor Calcium Release Channel/physiology | en |
dc.title | Nitric oxide-induced calcium release via ryanodine receptors regulates neuronal function. | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.ncid | AA10627582 | - |
dc.identifier.jtitle | The EMBO journal | en |
dc.identifier.volume | 31 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 417 | - |
dc.identifier.epage | 428 | - |
dc.relation.doi | 10.1038/emboj.2011.386 | - |
dc.textversion | author | - |
dc.identifier.pmid | 22036948 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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