Access count of this item: 104

Files in This Item:
File Description SizeFormat 
journal.pone.0043277.pdf1.28 MBAdobe PDFView/Open
Title: Eco-Geographical Diversification of Bitter Taste Receptor Genes (TAS2Rs) among Subspecies of Chimpanzees (Pan troglodytes).
Authors: Hayakawa, Takashi  kyouindb  KAKEN_id
Sugawara, Tohru
Go, Yasuhiro
Udono, Toshifumi
Hirai, Hirohisa  kyouindb  KAKEN_id
Imai, Hiroo  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0003-0729-0322 (unconfirmed)
Author's alias: 今井, 啓雄
Issue Date: 16-Aug-2012
Publisher: Public Library of Science
Journal title: PloS one
Volume: 7
Issue: 8
Thesis number: e43277
Abstract: Chimpanzees (Pan troglodytes) have region-specific difference in dietary repertoires from East to West across tropical Africa. Such differences may result from different genetic backgrounds in addition to cultural variations. We analyzed the sequences of all bitter taste receptor genes (cTAS2Rs) in a total of 59 chimpanzees, including 4 putative subspecies. We identified genetic variations including single-nucleotide variations (SNVs), insertions and deletions (indels), gene-conversion variations, and copy-number variations (CNVs) in cTAS2Rs. Approximately two-thirds of all cTAS2R haplotypes in the amino acid sequence were unique to each subspecies. We analyzed the evolutionary backgrounds of natural selection behind such diversification. Our previous study concluded that diversification of cTAS2Rs in western chimpanzees (P. t. verus) may have resulted from balancing selection. In contrast, the present study found that purifying selection dominates as the evolutionary form of diversification of the so-called human cluster of cTAS2Rs in eastern chimpanzees (P. t. schweinfurthii) and that the other cTAS2Rs were under no obvious selection as a whole. Such marked diversification of cTAS2Rs with different evolutionary backgrounds among subspecies of chimpanzees probably reflects their subspecies-specific dietary repertoires.
Rights: © 2012 Hayakawa et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
URI: http://hdl.handle.net/2433/159503
DOI(Published Version): 10.1371/journal.pone.0043277
PubMed ID: 22916235
Appears in Collections:Journal Articles

Show full item record

Export to RefWorks


Export Format: 


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.