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Title: Relationship between periodontitis-related antibody and frequent exacerbations in chronic obstructive pulmonary disease.
Authors: Takahashi, Tamaki
Muro, Shigeo  kyouindb  KAKEN_id
Tanabe, Naoya  kyouindb  KAKEN_id
Terada, Kunihiko
Kiyokawa, Hirofumi
Sato, Susumu  kyouindb  KAKEN_id  orcid (unconfirmed)
Hoshino, Yuma
Ogawa, Emiko
Uno, Kazuko
Naruishi, Koji
Takashiba, Shogo
Mishima, Michiaki
Author's alias: 室, 繁郎
Issue Date: 11-Jul-2012
Publisher: Public Library of Science
Journal title: PloS one
Volume: 7
Issue: 7
Thesis number: e40570
Abstract: [Background]To identify patients with chronic obstructive pulmonary disease (COPD) who are susceptible to frequent exacerbations is important. Although periodontitis aggravated by poor oral hygiene might increase the risk of lower respiratory tract infection, the relationship between periodontitis and COPD exacerbations remains unknown. This prospective cohort study investigates the relationship between periodontitis-related antibody and exacerbation frequency over a one-year period. [Methods]We assessed an IgG antibody titer against Porphyromonas gingivalis, which is a major pathogen of periodontitis, and then prospectively followed up 93 individuals over one year to detect exacerbations. [Results]The numbers of exacerbations and the rate of individuals with frequent exacerbations (at least two per year) were significantly lower in patients with higher IgG titer than those with normal IgG titer (0.8 vs. 1.2 per year, p = 0.045 and 14.3 vs. 38.6%, p = 0.009, respectively). Multivariate logistic regression analysis showed that being normal-IgG titer for periodontitis-related antibody significantly increased the risk of frequent exacerbations (relative risk, 5.27, 95% confidence interval, 1.30–25.7; p = 0.019) after adjusting for other possible confounders, such as a history of exacerbations in the past year, disease severity, COPD medication and smoking status. [Conclusions]Normal-IgG titer for periodontitis-related antibody can be an independent predictor of frequent exacerbations. Measuring periodontitis-related antibody titers might be useful to identify patients with susceptibility to frequent exacerbations so that an aggressive prevention strategy can be designed.
Rights: © 2012 Takahashi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
DOI(Published Version): 10.1371/journal.pone.0040570
PubMed ID: 22792372
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