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Title: Serum IgG levels demonstrate seasonal change in connective tissue diseases: a large-scale, 4-year analysis in Japanese.
Authors: Terao, Chikashi  kyouindb  KAKEN_id
Ohmura, Koichiro  kyouindb  KAKEN_id
Yamamoto, Keiichi
Yukawa, Naoichiro  KAKEN_id
Kawabata, Daisuke
Nojima, Takaki
Fujii, Takao  KAKEN_id
Mimori, Tsuneyo  kyouindb  KAKEN_id
Author's alias: 寺尾, 知可史
Keywords: Immunoglobulin
Connective tissue disease
Serologic marker
Systemic lupus erythematosus
Rheumatoid arthritis
Issue Date: Jun-2012
Publisher: Springer Japan
Journal title: Modern rheumatology / the Japan Rheumatism Association
Volume: 22
Issue: 3
Start page: 426
End page: 430
Abstract: Hypergammaglobulinemia is often found in patients with autoimmune diseases, such as systemic lupus erythematosus (SLE), and its level may correlate with disease activity. However, it is unclear whether immunoglobulin G (IgG) displays seasonal changes. We analyzed the seasonal change in serum IgG by assessing 450 patients with connective tissue disease. The serum IgG levels in summer were compared with those in winter from 2006 to 2009. Independent samples from 355 patients were analyzed to confirm results in the first set. The differences in the IgG levels between the two seasons were analyzed in each disease and compared with disease activity. 488 patients without connective tissue disease were analyzed as reference instead of healthy people as control. We found that connective tissue disease patients tended to show higher levels of serum IgG in summer than in winter every year from 2006 to 2009, whereas patients without connective tissue disease did not demonstrate such a tendency. We observed this seasonal tendency in each disease. Seasonal changes weakly correlated with those of anti-DNA antibody in SLE patients and those of disease activity score in rheumatoid arthritis (RA) patients. Serum IgG levels of patients with connective tissue diseases display seasonal variations. Biological and clinical significance of these variations should be elucidated.
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This is not the published version. Please cite only the published version.
DOI(Published Version): 10.1007/s10165-011-0535-3
PubMed ID: 21984128
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