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タイトル: | Increased incidence of osteonecrosis of the jaw after tooth extraction in patients treated with bisphosphonates: a cohort study. |
著者: | Yamazaki, T Yamori, M Ishizaki, T Asai, K ![]() Goto, K Takahashi, K ![]() Nakayama, T ![]() ![]() ![]() Bessho, K ![]() |
著者名の別形: | 山崎, 亨 家森, 正志 |
キーワード: | alveolar bone loss bisphosphonate incidence jaw osteonecrosis relative risk tooth extraction |
発行日: | Nov-2012 |
出版者: | Elsevier Ltd. |
誌名: | International journal of oral and maxillofacial surgery |
巻: | 41 |
号: | 11 |
開始ページ: | 1397 |
終了ページ: | 1403 |
抄録: | This study estimated the cumulative incidence and risk ratio for osteonecrosis of the jaw (ONJ) after tooth extraction in patients with and without administration of bisphosphonates (BP) and identified potential risk factors for bisphosphonate-induced osteonecrosis of the jaw (BIONJ). A cohort study was conducted in all patients undergoing tooth extraction at a university hospital in Japan from April 2006 to June 2009. Of 3216 patients, 126 had BP administration, of whom 5 (3.9%, 95% confidence interval (CI): 1.2-9.2) developed ONJ, versus 1 (0.032%, 95% CI: 0.00081-0.18) among 3090 patients without BP administration. BP administration was associated with the development of ONJ after tooth extraction, with an unadjusted risk ratio of 122.6 (95% CI: 14.4-1041.8). When stratified by age and route of BP administration, the risk ratio for ONJ patients aged 65 years or older with intravenous BP administration compared to those without was 200.2 (95% CI: 23.8-1679.4, P<0.001). Patients receiving BP showed a significant association between the incidence of BIONJ and alveolar bone loss score. The risk of ONJ is higher in patients with than without BP administration, particularly intravenous administration. Severe periodontitis might be a risk factor for BIONJ. |
著作権等: | © 2012 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/160871 |
DOI(出版社版): | 10.1016/j.ijom.2012.06.020 |
PubMed ID: | 22840716 |
出現コレクション: | 学術雑誌掲載論文等 |

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