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Title: Effect of preprocurement ventilation on lungs donated after cardiac death in a canine lung transplantation model.
Authors: Sakamoto, Jin
Chen, Fengshi
Yamada, Tetsu
Nakajima, Daisuke
Ohsumi, Akihiro
Kikuchi, Ryutaro
Zhao, Xiangdong  kyouindb  KAKEN_id
Fujinaga, Takuji
Shoji, Tsuyoshi
Sakai, Hiroaki
Bando, Toru
Date, Hiroshi  kyouindb  KAKEN_id
Author's alias: 阪本, 仁
伊達, 洋至
Keywords: lung transplantation
ventilation
donation after cardiac death
canine model
Issue Date: 27-Oct-2011
Publisher: Lippincott Williams & Wilkins, Inc.
Journal title: Transplantation
Volume: 92
Issue: 8
Start page: 864
End page: 870
Abstract: [Background.] One method of countering chronic lung donor shortages is the practice of donation after cardiac death (DCD). However, this technique inevitably leads to pulmonary dysfunction related to warm ischemia. One promising method of alleviating this problem is ventilation. However, it can rarely be initiated from the onset of cardiac arrest, particularly in uncontrolled DCD donors. We investigated the protective effect of the last 60 min of ventilation during a 240-min warm ischemic time. [Methods.] We rendered donor dogs cardiac dead and left them at room temperature. Six dogs received ventilation with 100% oxygen for 60 min starting at 180 min after cardiac arrest (ventilation group). Eight dogs received no ventilation. Lungs were harvested 240 min after cardiac arrest, then transplanted into recipient dogs. At 60 min after reperfusion, the right pulmonary artery was ligated, and the function of the left transplanted lung was evaluated. [Results.] In the ventilation group, all six animals survived for 240 min after reperfusion, whereas in the nonventilation group, only four of eight survived. The ventilation group demonstrated significantly better pulmonary oxygenation, shunt fraction, and wet-to-dry weight ratio. Furthermore, the ventilation group revealed significantly higher levels of high-energy phosphates in the lung tissues, fewer apoptotic cells, lower levels of tumor necrosis factor-α and interleukin-8 messenger RNA in the lung tissues, and lower levels of interleukin-6 messenger RNA in the serum. [Conclusion.] Our results suggest that ventilation during the late phase of the preprocurement period may ameliorate ischemia-reperfusion injury in DCD donors.
Rights: © 2011 Lippincott Williams & Wilkins, Inc.
この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。This is not the published version. Please cite only the published version.
URI: http://hdl.handle.net/2433/162547
DOI(Published Version): 10.1097/TP.0b013e31822d87c6
PubMed ID: 21876480
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