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dc.contributor.authorSakamoto, Jinja
dc.contributor.authorChen, Fengshija
dc.contributor.authorYamada, Tetsuja
dc.contributor.authorNakajima, Daisukeja
dc.contributor.authorOhsumi, Akihiroja
dc.contributor.authorKikuchi, Ryutaroja
dc.contributor.authorZhao, Xiangdongja
dc.contributor.authorFujinaga, Takujija
dc.contributor.authorShoji, Tsuyoshija
dc.contributor.authorSakai, Hiroakija
dc.contributor.authorBando, Toruja
dc.contributor.authorDate, Hiroshija
dc.contributor.alternative阪本, 仁ja
dc.contributor.alternative伊達, 洋至ja
dc.date.accessioned2012-11-30T01:03:51Z-
dc.date.available2012-11-30T01:03:51Z-
dc.date.issued2011-10-27ja
dc.identifier.issn0041-1337ja
dc.identifier.urihttp://hdl.handle.net/2433/162547-
dc.description.abstract[Background.] One method of countering chronic lung donor shortages is the practice of donation after cardiac death (DCD). However, this technique inevitably leads to pulmonary dysfunction related to warm ischemia. One promising method of alleviating this problem is ventilation. However, it can rarely be initiated from the onset of cardiac arrest, particularly in uncontrolled DCD donors. We investigated the protective effect of the last 60 min of ventilation during a 240-min warm ischemic time. [Methods.] We rendered donor dogs cardiac dead and left them at room temperature. Six dogs received ventilation with 100% oxygen for 60 min starting at 180 min after cardiac arrest (ventilation group). Eight dogs received no ventilation. Lungs were harvested 240 min after cardiac arrest, then transplanted into recipient dogs. At 60 min after reperfusion, the right pulmonary artery was ligated, and the function of the left transplanted lung was evaluated. [Results.] In the ventilation group, all six animals survived for 240 min after reperfusion, whereas in the nonventilation group, only four of eight survived. The ventilation group demonstrated significantly better pulmonary oxygenation, shunt fraction, and wet-to-dry weight ratio. Furthermore, the ventilation group revealed significantly higher levels of high-energy phosphates in the lung tissues, fewer apoptotic cells, lower levels of tumor necrosis factor-α and interleukin-8 messenger RNA in the lung tissues, and lower levels of interleukin-6 messenger RNA in the serum. [Conclusion.] Our results suggest that ventilation during the late phase of the preprocurement period may ameliorate ischemia-reperfusion injury in DCD donors.ja
dc.format.mimetypeapplication/pdfja
dc.language.isoengja
dc.publisherLippincott Williams & Wilkins, Inc.ja
dc.rights© 2011 Lippincott Williams & Wilkins, Inc.ja
dc.rightsこの論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。This is not the published version. Please cite only the published version.ja
dc.subjectlung transplantationja
dc.subjectventilationja
dc.subjectdonation after cardiac deathja
dc.subjectcanine modelja
dc.subject.meshAdenosine Triphosphate/analysisja
dc.subject.meshAnimalsja
dc.subject.meshApoptosisja
dc.subject.meshCytokines/bloodja
dc.subject.meshDogsja
dc.subject.meshLung/pathologyja
dc.subject.meshLung/physiologyja
dc.subject.meshLung Transplantationja
dc.subject.meshModels, Animalja
dc.subject.meshOrgan Preservation/methodsja
dc.subject.meshOrgan Sizeja
dc.subject.meshRespiration, Artificialja
dc.subject.meshTissue Donorsja
dc.titleEffect of preprocurement ventilation on lungs donated after cardiac death in a canine lung transplantation model.ja
dc.type.niitypeJournal Articleja
dc.identifier.ncidAA00868935ja
dc.identifier.jtitleTransplantationja
dc.identifier.volume92ja
dc.identifier.issue8ja
dc.identifier.spage864ja
dc.identifier.epage870ja
dc.relation.doi10.1097/TP.0b013e31822d87c6ja
dc.textversionauthorja
dc.identifier.pmid21876480ja
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