Access count of this item: 82

Files in This Item:
File Description SizeFormat 
jnsv.58.88.pdf711.45 kBAdobe PDFView/Open
Title: Blood Lactate Functions as a Signal for Enhancing Fatty Acid Metabolism during Exercise via TGF-β in the Brain
Authors: YAMADA, Hiroyuki
IWAKI, Yoko
KITAOKA, Ryo
FUJITANI, Mina
SHIBAKUSA, Tetsuro
FUJIKAWA, Teppei
MATSUMURA, Shigenobu  kyouindb  KAKEN_id
FUSHIKI, Tohru  KAKEN_id
INOUE, Kazuo  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0001-7003-8635 (unconfirmed)
Author's alias: 井上, 和生
Keywords: lactate
TGF-β
exercise
respiratory gas analysis
spontaneous motor activity
Issue Date: 2012
Publisher: Center for Academic Publications Japan
Journal title: Journal of Nutritional Science and Vitaminology
Volume: 58
Issue: 2
Start page: 88
End page: 95
Abstract: Moderate-intensity running (treadmill velocity of 21 m/min) increased blood lactate and actived transforming growth factor-β (TGF-β) concentration in rat cerebrospinal fluid (CSF). On the other hand, low-intensity running (15 m/min) did not increase blood lactate and caused no change in CSF TGF-β. Intraperitoneal (i.p.) administration of lactate to anesthetized rats caused an increase in blood lactate similar to that observed after a 21 m/min running exercise and increased the level of active TGF-β in CSF. Intraperitoneal administration of lactate at the same dose to awake and unrestricted rats caused a decrease in the respiratory exchange ratio, that is, enhancement of fatty acid oxidation and depression of spontaneous motor activity (SMA). Given that intracisternal administration of TGF-β to rats has been reported to enhance fatty acid metabolism and to depress SMA, we surmise that the observed changes caused by i.p. lactate administration in this study were mediated, at least in part, by TGF-β in the brain.
Rights: © 2012 by the Center for Academic Publications Japan
URI: http://hdl.handle.net/2433/166073
DOI(Published Version): 10.3177/jnsv.58.88
Appears in Collections:Journal Articles

Show full item record

Export to RefWorks


Export Format: 


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.