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Title: Impaired endothelium-dependent vasodilator response in patients with pulmonary fibrosis.
Authors: Aihara, Kensaku
Handa, Tomohiro  kyouindb  KAKEN_id
Nagai, Sonoko
Tanizawa, Kiminobu  kyouindb  KAKEN_id
Ikezoe, Kohei
Watanabe, Kizuku
Chihara, Yuichi
Harada, Yuka
Yoshimura, Chikara
Oga, Toru  kyouindb  KAKEN_id
Ozasa, Neiko  kyouindb  KAKEN_id
Uno, Kazuko
Chin, Kazuo  kyouindb  KAKEN_id
Mishima, Michiaki
Author's alias: 半田, 知宏
Keywords: Digital pulse amplitude tonometry
Endothelial function
Pulmonary fibrosis
Reactive hyperemia
Issue Date: Feb-2013
Publisher: Elsevier Ltd.
Journal title: Respiratory medicine
Volume: 107
Issue: 2
Start page: 269
End page: 275
Abstract: [Background] Recent epidemiological evidence indicates an association between cardiovascular diseases and pulmonary fibrosis. The vascular endothelium acts to maintain vascular homeostasis through multiple mechanisms and impaired endothelial function can contribute to the development, progression and clinical expression of atherosclerosis. [Methods] We consecutively recruited 39 newly-diagnosed chronic interstitial pneumonitis/fibrosis patients without any specific etiology. We assessed endothelium-dependent vasodilator response of patients using digital pulse amplitude tonometry and compared the reactive hyperemia index (RHI) with age-, sex- and body mass index-matched control subjects (n = 30). We further investigated the relationships between RHI and clinical characteristics, laboratory cardiovascular risk factors, disease-related factors and circulating levels of inflammatory biomarkers. [Results] RHI was significantly lower in patients with chronic interstitial pneumonitis/fibrosis than in control subjects (p = 0.02). While circulating levels of total cholesterol, triglycerides, HbA1c and fasting glucose did not differ significantly between groups, patients with chronic interstitial pneumonitis/fibrosis had significantly lower high density lipoprotein levels and higher low density lipoprotein levels as compared with control subjects. Regarding disease-related factors, RHI was significantly associated with the diffusing capacity for carbon monoxide, alveolar-arterial oxygen pressure difference, 6-min walk distance and end-exercise oxygen saturation. Additionally, circulating levels of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 were inversely correlated with RHI. [Conclusions] We confirmed a possible link between pulmonary fibrosis and cardiovascular disease by demonstrating an impairment of endothelium-dependent vasodilator response, which was significantly associated with the severity of pulmonary fibrosis and circulating levels of adhesion molecules.
Rights: © 2012 Elsevier Ltd.
この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。This is not the published version. Please cite only the published version.
DOI(Published Version): 10.1016/j.rmed.2012.10.005
PubMed ID: 23102612
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