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| ファイル | 記述 | サイズ | フォーマット | |
|---|---|---|---|---|
| j.addr.2012.11.006.pdf | 369.45 kB | Adobe PDF | 見る/開く |
| タイトル: | Pharmacokinetic considerations for targeted drug delivery. |
| 著者: | Yamashita, Fumiyoshi    https://orcid.org/0000-0002-3503-8696 (unconfirmed)Hashida, Mitsuru |
| 著者名の別形: | 山下, 富義 橋田, 充 |
| キーワード: | Drug delivery system Targeted drug delivery Pharmacokinetics Tissue uptake clearance Macromolecular prodrugs Chemical modified proteins Nanoparticles Liposomes |
| 発行日: | Jan-2013 |
| 出版者: | Elsevier BV |
| 誌名: | Advanced drug delivery reviews |
| 巻: | 65 |
| 号: | 1 |
| 開始ページ: | 139 |
| 終了ページ: | 147 |
| 抄録: | Drug delivery systems involve technology designed to maximize therapeutic efficacy of drugs by controlling their biodistribution profile. In order to optimize a function of the delivery systems, their biodistribution characteristics should be systematically understood. Pharmacokinetic analysis based on the clearance concepts provides quantitative information of the biodistribution, which can be related to physicochemical properties of the delivery system. Various delivery systems including macromolecular drug conjugates, chemically or genetically modified proteins, and particulate drug carriers have been designed and developed so far. In this article, we review physiological and pharmacokinetic implications of the delivery systems. |
| 著作権等: | © 2013 Published by Elsevier B.V. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
| URI: | http://hdl.handle.net/2433/170274 |
| DOI(出版社版): | 10.1016/j.addr.2012.11.006 |
| PubMed ID: | 23280371 |
| 出現コレクション: | 学術雑誌掲載論文等 |
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