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タイトル: The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43
著者: Kimura, Ikuo
Ozawa, Kentaro
Inoue, Daisuke
Imamura, Takeshi
Kimura, Kumi
Maeda, Takeshi
Terasawa, Kazuya
Kashihara, Daiji
Hirano, Kanako
Tani, Taeko
Takahashi, Tomoyuki
Miyauchi, Satoshi
Shioi, Go
Inoue, Hiroshi
Tsujimoto, Gozoh
著者名の別形: 木村, 郁夫
キーワード: Biological sciences
Medical research
Microbiology
発行日: 7-May-2013
出版者: Nature Publishing Group
誌名: Nature communications
巻: 4
論文番号: 1829
抄録: The gut microbiota affects nutrient acquisition and energy regulation of the host, and can influence the development of obesity, insulin resistance, and diabetes. During feeding, gut microbes produce short-chain fatty acids, which are important energy sources for the host. Here we show that the short-chain fatty acid receptor GPR43 links the metabolic activity of the gut microbiota with host body energy homoeostasis. We demonstrate that GPR43-deficient mice are obese on a normal diet, whereas mice overexpressing GPR43 specifically in adipose tissue remain lean even when fed a high-fat diet. Raised under germ-free conditions or after treatment with antibiotics, both types of mice have a normal phenotype. We further show that short-chain fatty acid-mediated activation of GPR43 suppresses insulin signalling in adipocytes, which inhibits fat accumulation in adipose tissue and promotes the metabolism of unincorporated lipids and glucose in other tissues. These findings establish GPR43 as a sensor for excessive dietary energy, thereby controlling body energy utilization while maintaining metabolic homoeostasis.
記述: 腸内細菌による宿主のエネルギー恒常性維持機構の解明 : 短鎖脂肪酸受容体GPR43活性化は脂肪の蓄積を抑制し肥満を防ぐ. 京都大学プレスリリース. 2013-05-08.
著作権等: © 2013 Nature Publishing Group
This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
URI: http://hdl.handle.net/2433/173824
DOI(出版社版): 10.1038/ncomms2852
PubMed ID: 23652017
関連リンク: http://www.kyoto-u.ac.jp/ja/news_data/h/h1/news6/2013/130508_1.htm
出現コレクション:学術雑誌掲載論文等

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