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タイトル: | The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43 |
著者: | Kimura, Ikuo https://orcid.org/0000-0001-8778-145X (unconfirmed) Ozawa, Kentaro Inoue, Daisuke Imamura, Takeshi Kimura, Kumi Maeda, Takeshi Terasawa, Kazuya Kashihara, Daiji Hirano, Kanako Tani, Taeko Takahashi, Tomoyuki Miyauchi, Satoshi Shioi, Go Inoue, Hiroshi Tsujimoto, Gozoh |
著者名の別形: | 木村, 郁夫 |
キーワード: | Biological sciences Medical research Microbiology |
発行日: | 7-May-2013 |
出版者: | Nature Publishing Group |
誌名: | Nature communications |
巻: | 4 |
論文番号: | 1829 |
抄録: | The gut microbiota affects nutrient acquisition and energy regulation of the host, and can influence the development of obesity, insulin resistance, and diabetes. During feeding, gut microbes produce short-chain fatty acids, which are important energy sources for the host. Here we show that the short-chain fatty acid receptor GPR43 links the metabolic activity of the gut microbiota with host body energy homoeostasis. We demonstrate that GPR43-deficient mice are obese on a normal diet, whereas mice overexpressing GPR43 specifically in adipose tissue remain lean even when fed a high-fat diet. Raised under germ-free conditions or after treatment with antibiotics, both types of mice have a normal phenotype. We further show that short-chain fatty acid-mediated activation of GPR43 suppresses insulin signalling in adipocytes, which inhibits fat accumulation in adipose tissue and promotes the metabolism of unincorporated lipids and glucose in other tissues. These findings establish GPR43 as a sensor for excessive dietary energy, thereby controlling body energy utilization while maintaining metabolic homoeostasis. |
記述: | 腸内細菌による宿主のエネルギー恒常性維持機構の解明 : 短鎖脂肪酸受容体GPR43活性化は脂肪の蓄積を抑制し肥満を防ぐ. 京都大学プレスリリース. 2013-05-08. |
著作権等: | © 2013 Nature Publishing Group This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ |
URI: | http://hdl.handle.net/2433/173824 |
DOI(出版社版): | 10.1038/ncomms2852 |
PubMed ID: | 23652017 |
関連リンク: | http://www.kyoto-u.ac.jp/ja/news_data/h/h1/news6/2013/130508_1.htm |
出現コレクション: | 学術雑誌掲載論文等 |
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