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| c2ob25298h.pdf | 228.93 kB | Adobe PDF | 見る/開く |
| タイトル: | Design and synthesis of a novel class of CK2 inhibitors: application of copper- and gold-catalysed cascade reactions for fused nitrogen heterocycles. |
| 著者: | Suzuki, Yamato Oishi, Shinya   https://orcid.org/0000-0002-2833-2539 (unconfirmed)Takei, Yoshinori Yasue, Misato Misu, Ryosuke Naoe, Saori Hou, Zengye Kure, Tatsuhide Nakanishi, Isao Ohno, Hiroaki  https://orcid.org/0000-0002-3246-4809 (unconfirmed)Hirasawa, Akira https://orcid.org/0000-0001-5692-805X (unconfirmed)Tsujimoto, Gozoh Fujii, Nobutaka |
| 著者名の別形: | 大石, 真也 |
| 発行日: | 25-Apr-2012 |
| 出版者: | Royal Society of Chemistry |
| 誌名: | Organic & biomolecular chemistry |
| 巻: | 10 |
| 号: | 25 |
| 開始ページ: | 4907 |
| 終了ページ: | 4915 |
| 抄録: | Two classes of fused nitrogen heterocycles were designed as CK2 inhibitor candidates on the basis of previous structure-activity relationship (SAR) studies. Various dipyrrolo[3, 2-b:2', 3'-e]pyridine and benzo[g]indazole derivatives were prepared using transition-metal-catalysed cascade and/or multicomponent reactions. Biological evaluation of these candidates revealed that benzo[g]indazole is a promising scaffold for potent CK2 inhibitors. The inhibitory activities on cell proliferation of these potent CK2 inhibitors are also presented. |
| 著作権等: | © The Royal Society of Chemistry 2012 This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
| URI: | http://hdl.handle.net/2433/174130 |
| DOI(出版社版): | 10.1039/c2ob25298h |
| PubMed ID: | 22610034 |
| 出現コレクション: | 学術雑誌掲載論文等 |
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