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Title: Design and synthesis of a novel class of CK2 inhibitors: application of copper- and gold-catalysed cascade reactions for fused nitrogen heterocycles.
Authors: Suzuki, Yamato
Oishi, Shinya  kyouindb  KAKEN_id  orcid (unconfirmed)
Takei, Yoshinori  kyouindb  KAKEN_id
Yasue, Misato
Misu, Ryosuke
Naoe, Saori
Hou, Zengye
Kure, Tatsuhide
Nakanishi, Isao
Ohno, Hiroaki  kyouindb  KAKEN_id  orcid (unconfirmed)
Hirasawa, Akira  kyouindb  KAKEN_id  orcid (unconfirmed)
Tsujimoto, Gozoh
Fujii, Nobutaka  KAKEN_id
Author's alias: 大石, 真也
Issue Date: 25-Apr-2012
Publisher: Royal Society of Chemistry
Journal title: Organic & biomolecular chemistry
Volume: 10
Issue: 25
Start page: 4907
End page: 4915
Abstract: Two classes of fused nitrogen heterocycles were designed as CK2 inhibitor candidates on the basis of previous structure-activity relationship (SAR) studies. Various dipyrrolo[3, 2-b:2', 3'-e]pyridine and benzo[g]indazole derivatives were prepared using transition-metal-catalysed cascade and/or multicomponent reactions. Biological evaluation of these candidates revealed that benzo[g]indazole is a promising scaffold for potent CK2 inhibitors. The inhibitory activities on cell proliferation of these potent CK2 inhibitors are also presented.
Rights: © The Royal Society of Chemistry 2012
This is not the published version. Please cite only the published version.
DOI(Published Version): 10.1039/c2ob25298h
PubMed ID: 22610034
Appears in Collections:Journal Articles

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