|Title:||Design and synthesis of a novel class of CK2 inhibitors: application of copper- and gold-catalysed cascade reactions for fused nitrogen heterocycles.|
Oishi, Shinya https://orcid.org/0000-0002-2833-2539 (unconfirmed)
Ohno, Hiroaki https://orcid.org/0000-0002-3246-4809 (unconfirmed)
Hirasawa, Akira https://orcid.org/0000-0001-5692-805X (unconfirmed)
|Author's alias:||大石, 真也|
|Publisher:||Royal Society of Chemistry|
|Journal title:||Organic & biomolecular chemistry|
|Abstract:||Two classes of fused nitrogen heterocycles were designed as CK2 inhibitor candidates on the basis of previous structure-activity relationship (SAR) studies. Various dipyrrolo[3, 2-b:2', 3'-e]pyridine and benzo[g]indazole derivatives were prepared using transition-metal-catalysed cascade and/or multicomponent reactions. Biological evaluation of these candidates revealed that benzo[g]indazole is a promising scaffold for potent CK2 inhibitors. The inhibitory activities on cell proliferation of these potent CK2 inhibitors are also presented.|
|Rights:||© The Royal Society of Chemistry 2012|
This is not the published version. Please cite only the published version.
|Appears in Collections:||Journal Articles|
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