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Title: Pre-SMA actively engages in conflict processing in human: A combined study of epicortical ERPs and direct cortical stimulation.
Authors: Usami, Kiyohide  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0003-2257-8279 (unconfirmed)
Matsumoto, Riki  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0003-3985-9210 (unconfirmed)
Kunieda, Takeharu  KAKEN_id
Shimotake, Akihiro  kyouindb  KAKEN_id
Matsuhashi, Masao  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0003-2385-1265 (unconfirmed)
Miyamoto, Susumu  kyouindb  KAKEN_id
Fukuyama, Hidenao  KAKEN_id
Takahashi, Ryosuke  kyouindb  KAKEN_id
Ikeda, Akio  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-0790-2598 (unconfirmed)
Author's alias: 松本, 理器
Keywords: Pre-SMA
Conflict processing
Medial frontal cortex
Direct cortical stimulation
Event-related potential
Issue Date: Apr-2013
Publisher: Elsevier Ltd.
Journal title: Neuropsychologia
Volume: 51
Issue: 5
Start page: 1011
End page: 1017
Abstract: Previous non-invasive studies have proposed that the deeply seated region of the medial frontal cortex engages in conflict processing in humans, but its core region has remained to be elucidated. By means of direct cortical stimulation, which excels other techniques in temporal and spatial resolutions and in the capacity of producing transient, functional impairment even in the deeply located cortices, we attempted to obtain direct evidence that the pre-supplementary motor area (pre-SMA) actively engages in conflict processing. Subject was a patient with right frontal lobe epilepsy who underwent invasive presurgical evaluation with subdural electrodes placed on the medial and lateral frontal cortices. During a conflict task - modified Eriksen flanker task, direct cortical stimulation was delivered time-locked to the task at the inferior part of the medial superior frontal gyrus (inferior medial SFG), the superior part of the medial SFG, and the middle frontal gyrus. By adopting the session of sham stimulation that was employed as a within-block control, event-related potentials (ERPs) were recorded from the medial and lateral frontal cortices. The inferior medial SFG showed a significant ERP difference between trials with more and less conflict, while the other frontal cortices did not. Among the three stimulus sites, only stimulation of the inferior medial SFG significantly prolonged reaction time in trials with more conflict. Anatomically, the inferior medial SFG corresponded with the pre-SMA (Brodmann area 8). It was located 1-2cm rostral to the vertical anterior commissure line where cortical stimulation elicited arrest of motion (the supplementary negative motor area). Functionally, this area corresponded to the dorso-rostral portion of the activation loci in previous neuroimaging studies focusing on conflict processing. By combining epicortical ERP recording and direct cortical stimulation in a human brain, this study, for the first time, presented one direct piece of evidence that the pre-SMA actively participates in conflict processing.
Rights: © 2013 Elsevier Ltd.
この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。This is not the published version. Please cite only the published version.
URI: http://hdl.handle.net/2433/174131
DOI(Published Version): 10.1016/j.neuropsychologia.2013.02.002
PubMed ID: 23411010
Appears in Collections:Journal Articles

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