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Title: Sequence-specific electron injection into DNA from an intermolecular electron donor.
Authors: Morinaga, Hironobu
Takenaka, Tomohiro
Hashiya, Fumitaka
Kizaki, Seiichiro
Hashiya, Kaori
Bando, Toshikazu  kyouindb  KAKEN_id
Sugiyama, Hiroshi  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0001-8923-5946 (unconfirmed)
Author's alias: 杉山, 弘
Issue Date: 1-Apr-2013
Publisher: Oxford University Press.
Journal title: Nucleic acids research
Volume: 41
Issue: 8
Start page: 4724
End page: 4728
Abstract: Electron transfer in DNA has been intensively studied to elucidate its biological roles and for applications in bottom-up DNA nanotechnology. Recently, mechanisms of electron transfer to DNA have been investigated; however, most of the systems designed are intramolecular. Here, we synthesized pyrene-conjugated pyrrole-imidazole polyamides (PPIs) to achieve sequence-specific electron injection into DNA in an intermolecular fashion. Electron injection from PPIs into DNA was detected using 5-bromouracil as an electron acceptor. Twelve different 5-bromouracil-containing oligomers were synthesized to examine the electron-injection ability of PPI. Product analysis demonstrated that the electron transfer from PPIs was localized in a range of 8 bp from the binding site of the PPIs. These results demonstrate that PPIs can be a useful tool for sequence-specific electron injection.
Rights: © The Author(s) 2013. Published by Oxford University Press.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
URI: http://hdl.handle.net/2433/174316
DOI(Published Version): 10.1093/nar/gkt123
PubMed ID: 23439569
Appears in Collections:Journal Articles

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