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タイトル: | Sequence-specific electron injection into DNA from an intermolecular electron donor. |
著者: | Morinaga, Hironobu Takenaka, Tomohiro Hashiya, Fumitaka Kizaki, Seiichiro Hashiya, Kaori Bando, Toshikazu Sugiyama, Hiroshi https://orcid.org/0000-0001-8923-5946 (unconfirmed) |
著者名の別形: | 杉山, 弘 |
発行日: | 1-Apr-2013 |
出版者: | Oxford University Press. |
誌名: | Nucleic acids research |
巻: | 41 |
号: | 8 |
開始ページ: | 4724 |
終了ページ: | 4728 |
抄録: | Electron transfer in DNA has been intensively studied to elucidate its biological roles and for applications in bottom-up DNA nanotechnology. Recently, mechanisms of electron transfer to DNA have been investigated; however, most of the systems designed are intramolecular. Here, we synthesized pyrene-conjugated pyrrole-imidazole polyamides (PPIs) to achieve sequence-specific electron injection into DNA in an intermolecular fashion. Electron injection from PPIs into DNA was detected using 5-bromouracil as an electron acceptor. Twelve different 5-bromouracil-containing oligomers were synthesized to examine the electron-injection ability of PPI. Product analysis demonstrated that the electron transfer from PPIs was localized in a range of 8 bp from the binding site of the PPIs. These results demonstrate that PPIs can be a useful tool for sequence-specific electron injection. |
著作権等: | © The Author(s) 2013. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
URI: | http://hdl.handle.net/2433/174316 |
DOI(出版社版): | 10.1093/nar/gkt123 |
PubMed ID: | 23439569 |
出現コレクション: | 学術雑誌掲載論文等 |
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