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Title: EFA6 activates Arf6 and participates in its targeting to the Flemming body during cytokinesis.
Authors: Ueda, Tomoko
Hanai, Ayako
Takei, Tomomi
Kubo, Keiji
Ohgi, Minako
Sakagami, Hiroyuki
Takahashi, Senye
Shin, Hye-Won  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-9138-9554 (unconfirmed)
Nakayama, Kazuhisa  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0001-7701-7183 (unconfirmed)
Author's alias: 中山, 和久
Keywords: Arf6
Cleavage furrow
Cytokinesis
EFA6
Flemming body
PH domain
Issue Date: 5-Jun-2013
Publisher: Elsevier B.V.
Journal title: FEBS letters
Volume: 587
Issue: 11
Start page: 1617
End page: 1623
Abstract: The small GTPase Arf6 is transiently associated with the ingressing cleavage furrow and subsequently targeted to the Flemming body during cytokinesis, suggesting its activation around the cleavage furrow. Here, we show that EFA6 (exchange factor for Arf6) localizes on the cleavage furrow through its PH domain. Time-lapse analysis showed that both EFA6 and Arf6 are transiently localized around the ingressing cleavage furrow, but only Arf6 is subsequently targeted to the Flemming body. Expression of an EFA6 mutant suppresses Arf6 recruitment onto the Flemming body. These results suggest that EFA6 participates in activation of Arf6 around the cleavage furrow during cytokinesis.
Rights: © 2013 Federation of European Biochemical Societies. Published by Elsevier B.V.
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
URI: http://hdl.handle.net/2433/175267
DOI(Published Version): 10.1016/j.febslet.2013.03.042
PubMed ID: 23603394
Appears in Collections:Journal Articles

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