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j.neuropharm.2013.03.033.pdf | 1.76 MB | Adobe PDF | 見る/開く |
タイトル: | Electroconvulsive seizures activate anorexigenic signals in the ventromedial nuclei of the hypothalamus. |
著者: | Segi-Nishida, Eri Sukeno, Mamiko Imoto, Yuki Kira, Toshihiko Sakaida, Mari Tsuchiya, Soken Sugimoto, Yukihiko Okuno, Yasushi |
著者名の別形: | 瀬木-西田, 恵里 |
キーワード: | Electroconvulsive seizure Ventromedial nucleus hypothalamus Laser-capture microdissection Anorexigenic signals |
発行日: | Aug-2013 |
出版者: | Elsevier Ltd. |
誌名: | Neuropharmacology |
巻: | 71 |
開始ページ: | 164 |
終了ページ: | 173 |
抄録: | The ventromedial nucleus of the hypothalamus (VMH) plays an important role in feeding and energy homeostasis. Electroconvulsive seizure (ECS) therapy is highly effective in the treatment of several psychiatric diseases, including depression, but may also have beneficial effects in other neurological diseases. Although it has been reported that the neurons of the VMH are strongly activated by ECS stimulation, the specific effects of ECS in this hypothalamic subnucleus remain unknown. To address this issue, we investigated the changes in gene expression in microdissected-VMH samples in response to ECS in mice, and examined the behavioral effects of ECS on feeding behavior. ECS significantly induced the expression of immediate-early genes such as Fos, Fosb, and Jun, as well as Bdnf, Adcyap1, Hrh1, and Crhr2 in the VMH. Given that signals of these gene products are suggested to have anorexigenic roles in the VMH, we also examined the effect of ECS on food intake and body weight. Repeated ECS had a suppressive effect on food intake and body weight gain under both regular and high-fat diet conditions. Furthermore, gold-thioglucose-induced hypothalamic lesions, including the VMH and the arcuate nucleus, abolished the anorexigenic effects of ECS, indicating the requirement for the activation of the hypothalamus. Our data show an effect of ECS on increased expression of anorexigenic factors in the VMH, and suggest a role in the regulation of energy homeostasis by ECS. |
著作権等: | © 2013 Elsevier Ltd. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/175281 |
DOI(出版社版): | 10.1016/j.neuropharm.2013.03.033 |
PubMed ID: | 23603200 |
出現コレクション: | 学術雑誌掲載論文等 |
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