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タイトル: | Xk-Related Protein 8 and CED-8 Promote Phosphatidylserine Exposure in Apoptotic Cells |
著者: | Suzuki, Jun ![]() Denning, Daniel P Imanishi, Eiichi Horvitz, H Robert Nagata, Shigekazu ![]() |
著者名の別形: | 長田, 重一 |
発行日: | 11-Jul-2013 |
出版者: | American Association for the Advancement of Science |
誌名: | Science |
巻: | 341 |
号: | 6144 |
開始ページ: | 403 |
終了ページ: | 406 |
抄録: | A classic feature of apoptotic cells is the cell-surface exposure of phosphatidylserine (PtdSer) as an "eat me" signal for engulfment. We show that the Xk-family protein Xkr8 mediates PtdSer exposure in response to apoptotic stimuli. Mouse Xkr8(-/-) cells or human cancer cells in which Xkr8 expression was repressed by hypermethylation failed to expose PtdSer during apoptosis and were inefficiently engulfed by phagocytes. Xkr8 was activated directly by caspases and required a caspase-3 cleavage site for its function. CED-8, the only Caenorhabditis elegans Xk-family homolog, also promoted apoptotic PtdSer exposure and cell-corpse engulfment. Thus, Xk-family proteins have evolutionarily conserved roles in promoting the phagocytosis of dying cells by altering the phospholipid distribution in the plasma membrane. |
記述: | アポトーシス時のリン脂質暴露に関与する因子の同定. 京都大学プレスリリース. 2013-07-12. |
著作権等: | © 2013 American Association for the Advancement of Science. This is the author's version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science on July 11 2013, DOI: 10.1126/science.1236758. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/176304 |
DOI(出版社版): | 10.1126/science.1236758 |
PubMed ID: | 23845944 |
関連リンク: | https://www.kyoto-u.ac.jp/static/ja/news_data/h/h1/news6/2013/130712_1.htm |
出現コレクション: | 学術雑誌掲載論文等 |
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