ダウンロード数: 273
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
jbc.M112.367011.pdf | 1.13 MB | Adobe PDF | 見る/開く |
タイトル: | Exercise is more effective than diet control in preventing high fat diet-induced β-amyloid deposition and memory deficit in amyloid precursor protein transgenic mice. |
著者: | Maesako, Masato Uemura, Kengo Kubota, Masakazu Kuzuya, Akira Sasaki, Kazuki Hayashida, Naoko Asada-Utsugi, Megumi Watanabe, Kiwamu Uemura, Maiko Kihara, Takeshi Takahashi, Ryosuke https://orcid.org/0000-0002-1407-9640 (unconfirmed) Shimohama, Shun Kinoshita, Ayae |
著者名の別形: | 木下, 彩栄 |
キーワード: | Alzheimer Disease Amyloid Diabetes Diet Exercise |
発行日: | 29-Jun-2012 |
出版者: | American Society for Biochemistry and Molecular Biology |
誌名: | The Journal of biological chemistry |
巻: | 287 |
号: | 27 |
開始ページ: | 23024 |
終了ページ: | 23033 |
抄録: | Accumulating evidence suggests that some dietary patterns, specifically high fat diet (HFD), increase the risk of developing sporadic Alzheimer disease (AD). Thus, interventions targeting HFD-induced metabolic dysfunctions may be effective in preventing the development of AD. We previously demonstrated that amyloid precursor protein (APP)-overexpressing transgenic mice fed HFD showed worsening of cognitive function when compared with control APP mice on normal diet. Moreover, we reported that voluntary exercise ameliorates HFD-induced memory impairment and β-amyloid (Aβ) deposition. In the present study, we conducted diet control to ameliorate the metabolic abnormality caused by HFD on APP transgenic mice and compared the effect of diet control on cognitive function with that of voluntary exercise as well as that of combined (diet control plus exercise) treatment. Surprisingly, we found that exercise was more effective than diet control, although both exercise and diet control ameliorated HFD-induced memory deficit and Aβ deposition. The production of Aβ was not different between the exercise- and the diet control-treated mice. On the other hand, exercise specifically strengthened the activity of neprilysin, the Aβ-degrading enzyme, the level of which was significantly correlated with that of deposited Aβ in our mice. Notably, the effect of the combination treatment (exercise and diet control) on memory and amyloid pathology was not significantly different from that of exercise alone. These studies provide solid evidence that exercise is a useful intervention to rescue HFD-induced aggravation of cognitive decline in transgenic model mice of AD. |
著作権等: | © 2012 by The American Society for Biochemistry and Molecular Biology, Inc. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 This is not the published version. Please cite only the published version. |
URI: | http://hdl.handle.net/2433/176995 |
DOI(出版社版): | 10.1074/jbc.M112.367011 |
PubMed ID: | 22563077 |
出現コレクション: | 学術雑誌掲載論文等 |
このリポジトリに保管されているアイテムはすべて著作権により保護されています。