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Title: Stromal plasma cells expressing immunoglobulin G4 subclass in non-small cell lung cancer.
Authors: Fujimoto, Masakazu  kyouindb  KAKEN_id
Yoshizawa, Akihiko  kyouindb  KAKEN_id
Sumiyoshi, Shinji
Sonobe, Makoto
Kobayashi, Masashi
Koyanagi, Itsuko
Aini, Wulamujiang
Tsuruyama, Tatsuaki  kyouindb  KAKEN_id
Date, Hiroshi
Haga, Hironori  kyouindb  KAKEN_id
Author's alias: 藤本, 正数
羽賀, 博典
Keywords: IgG4
Plasma cell
Lung carcinoma
Tissue microarray
Issue Date: Aug-2013
Publisher: Elsevier Inc.
Journal title: Human pathology
Volume: 44
Issue: 8
Start page: 1569
End page: 1576
Abstract: Inflammatory cell infiltration in tumor stroma may represent the interaction between the tumor and the immune system. The significance of immunoglobulin (Ig) G4+ plasmacytic infiltration, however, is poorly understood. Here, we analyzed the number of stromal IgG4+ plasma cells and the IgG4/IgG ratio of plasma cells in 294 primary non-small cell lung cancers (NSCLCs) using tissue microarray (TMA) and conventional surgical specimens. In TMA, 35 (12%) cases of NSCLC revealed more than 20 IgG4+ plasma cells per high-power field. In surgical specimens, most (97%) of those IgG4+ plasma cell-enriched cases showed obliterative phlebitis or arteritis, one of the key morphologic features of IgG4-related disease, within or at the periphery of the tumor. Clinically, none of the patients showed symptoms associated with IgG4-related systemic diseases. In patients with stage I squamous cell carcinoma, IgG4-enriched stroma was significantly associated with a favorable prognosis (P = .04). In conclusion, considerable IgG4+ plasma cell infiltration can be seen in a minority of cases of NSCLC and might contribute to prognostic modulation of NSCLC.
Rights: © 2013 Elsevier Inc.
この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。This is not the published version. Please cite only the published version.
DOI(Published Version): 10.1016/j.humpath.2013.01.002
PubMed ID: 23465276
Appears in Collections:Journal Articles

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