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タイトル: | Prevalence of plasmid-mediated AmpC β-lactamase-producing Escherichia coli and spread of the ST131 clone among extended-spectrum β-lactamase-producing E. coli in Japan. |
著者: | Matsumura, Yasufumi ![]() ![]() ![]() Yamamoto, Masaki ![]() ![]() Higuchi, Takeshi Komori, Toshiaki Tsuboi, Fusayuki Hayashi, Akihiko Sugimoto, Yoshihisa Hotta, Gou Matsushima, Aki ![]() ![]() Nagao, Miki ![]() ![]() ![]() Takakura, Shunji ![]() Ichiyama, Satoshi ![]() |
著者名の別形: | 松村, 康史 |
キーワード: | ESBL AmpC ST131 CTX-M-27 Prevalence |
発行日: | Aug-2012 |
出版者: | Elsevier B.V. |
誌名: | International journal of antimicrobial agents |
巻: | 40 |
号: | 2 |
開始ページ: | 158 |
終了ページ: | 162 |
抄録: | In 2010, a total of 1327 clinical Escherichia coli isolates from five hospitals in the Kyoto and Shiga regions of Japan were analysed by PCR. The prevalences of plasmid-mediated AmpC β-lactamase (pAmpC)-producers, extended-spectrum β-lactamase (ESBL)-producers and co-producers of pAmpC and ESBL were 1.7%, 9.7% and 0.3%, respectively. Less than one-half of the pAmpC-producers were reported to be resistant to third-generation cephalosporins, cephamycins and β-lactam/β-lactam inhibitors using the old 2009 Clinical and Laboratory Standards Institute (CLSI) breakpoints. CMY-2 was the most prevalent pAmpC type (95%), and CTX-M-14 (38%), CTX-M-15 (26%) and CTX-M-27 (19%) were the most prevalent ESBL types. The worldwide O25b-ST131-B2 clone accounted for 11% of pAmpC-producers and 41% of ESBL-producers. The O25b-ST131-B2 clone was characterised by a CTX-M-27- or CTX-M-15-type ESBL and ciprofloxacin-non-susceptibility with quadruple mutations in the quinolone resistance-determining regions (S83L and D87N in GyrA and S80I and E84V in ParC). A significant proportion of pAmpC-producers and the O25b-ST131-B2 clone were found in Japan by a recent regional surveillance programme. |
著作権等: | © 2012 Elsevier B.V. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 This is not the published version. Please cite only the published version. |
URI: | http://hdl.handle.net/2433/178036 |
DOI(出版社版): | 10.1016/j.ijantimicag.2012.04.013 |
PubMed ID: | 22743014 |
出現コレクション: | 学術雑誌掲載論文等 |

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