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Title: Prevalence of plasmid-mediated AmpC β-lactamase-producing Escherichia coli and spread of the ST131 clone among extended-spectrum β-lactamase-producing E. coli in Japan.
Authors: Matsumura, Yasufumi  kyouindb  KAKEN_id  orcid (unconfirmed)
Yamamoto, Masaki  kyouindb  KAKEN_id
Higuchi, Takeshi
Komori, Toshiaki
Tsuboi, Fusayuki
Hayashi, Akihiko
Sugimoto, Yoshihisa
Hotta, Gou
Matsushima, Aki  kyouindb  KAKEN_id
Nagao, Miki  kyouindb  KAKEN_id  orcid (unconfirmed)
Takakura, Shunji  kyouindb  KAKEN_id
Ichiyama, Satoshi  kyouindb  KAKEN_id
Author's alias: 松村, 康史
Keywords: ESBL
Issue Date: Aug-2012
Publisher: Elsevier B.V.
Journal title: International journal of antimicrobial agents
Volume: 40
Issue: 2
Start page: 158
End page: 162
Abstract: In 2010, a total of 1327 clinical Escherichia coli isolates from five hospitals in the Kyoto and Shiga regions of Japan were analysed by PCR. The prevalences of plasmid-mediated AmpC β-lactamase (pAmpC)-producers, extended-spectrum β-lactamase (ESBL)-producers and co-producers of pAmpC and ESBL were 1.7%, 9.7% and 0.3%, respectively. Less than one-half of the pAmpC-producers were reported to be resistant to third-generation cephalosporins, cephamycins and β-lactam/β-lactam inhibitors using the old 2009 Clinical and Laboratory Standards Institute (CLSI) breakpoints. CMY-2 was the most prevalent pAmpC type (95%), and CTX-M-14 (38%), CTX-M-15 (26%) and CTX-M-27 (19%) were the most prevalent ESBL types. The worldwide O25b-ST131-B2 clone accounted for 11% of pAmpC-producers and 41% of ESBL-producers. The O25b-ST131-B2 clone was characterised by a CTX-M-27- or CTX-M-15-type ESBL and ciprofloxacin-non-susceptibility with quadruple mutations in the quinolone resistance-determining regions (S83L and D87N in GyrA and S80I and E84V in ParC). A significant proportion of pAmpC-producers and the O25b-ST131-B2 clone were found in Japan by a recent regional surveillance programme.
Rights: © 2012 Elsevier B.V.
This is not the published version. Please cite only the published version.
DOI(Published Version): 10.1016/j.ijantimicag.2012.04.013
PubMed ID: 22743014
Appears in Collections:Journal Articles

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