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タイトル: | 根治的前立腺全摘除術症例における再発予測についての臨床的検討 |
その他のタイトル: | Retrospective Analysis of Predicting Biochemical Recurrence after Initial Radical Prostatectomy |
著者: | 南村, 和宏 小貫, 竜昭 河野, 充 石垣, 華子 加藤, 喜健 田尻, 雄大 澤田, 卓人 藤川, 敦 太田, 純一 森山, 正敏 林, 宏行 吉田, 幸子 原田, 昌興 |
著者名の別形: | Namura, Kazuhiro Onuki, Tatsuaki Kouno, Mitsuru Ishigaki, Hanako Kato, Yoshitake Tajiri, Takehiro Sawada, Takuto Fujikawa, Atsushi Ota, Junichi Moriyama, Masatoshi Hayashi, Hiroyuki Yoshida, Sachiko Harada, Masaoki |
キーワード: | Prostate cancer Prostatectomy Salvage radiotherapy |
発行日: | Aug-2013 |
出版者: | 泌尿器科紀要刊行会 |
誌名: | 泌尿器科紀要 |
巻: | 59 |
号: | 8 |
開始ページ: | 485 |
終了ページ: | 489 |
抄録: | We evaluated clinical outcomes of radical prostatectomy in 244 patients who had undergone radical prostatectomy as initial treatment from January 2000 to December 2011, and were followed up for more than 6 months. Biochemical recurrence after prostatectomy was defined as prostate-specific antigen (PSA) level of at least 0. 2 ng/ml. We evaluated potential risk factors for significant associations with biochemical recurrence. Median follow-up period after prostatectomy was 49 months (range, 6-144). Of the total, 192, 31, and 20 patients were at pathological stage pT2, pT3a, and pT3b, respectively. In 83 patients with the positive surgical margin, apexes were mostly in the positive area. Of the 68 patients with PSA recurrence, PSA non-relapse rate was 66.6% for 5 years. Multivariate analysis was performed for seminal vesicle invasion, PSA nadir, surgical margins, and Gleason score. Thirty-two patients with PSA recurrence underwent salvage radiotherapy, and the biochemical recurrence rate at 5 years was 73.8%. The group in which the PSA level before salvage radiotherapy was <0.5 ng/ml had a low rate of biochemical recurrence. We must consider the recurrence of poorly differentiated or non-confined cancer after radical prostatectomy. These results suggest that early use of salvage radiotherapy is effective for patients with biochemical recurrence after radical prostatectomy. |
著作権等: | 許諾条件により本文は2014-09-01に公開 |
URI: | http://hdl.handle.net/2433/178389 |
PubMed ID: | 23995523 |
出現コレクション: | Vol.59 No.8 |
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