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j.cyto.2013.07.011.pdf | 721.34 kB | Adobe PDF | 見る/開く |
タイトル: | Bmp4 expressed in preadipocytes is required for the onset of adipocyte differentiation |
著者: | Suenaga, Masashi Kurosawa, Norio Asano, Hiroki Kanamori, Yohei Umemoto, Takenao Yoshida, Hirofumi Murakami, Masaru Kawachi, Hiroyuki Matsui, Tohru ![]() ![]() Funaba, Masayuki ![]() ![]() ![]() |
著者名の別形: | 舟場, 正幸 |
キーワード: | Bmp4 Adipocyte differentiation Preadipocytes Interleukin-11 |
発行日: | Oct-2013 |
出版者: | Elsevier Ltd. |
誌名: | Cytokine |
巻: | 64 |
号: | 1 |
開始ページ: | 138 |
終了ページ: | 145 |
抄録: | We previously revealed that endogenous bone morphogenetic protein (Bmp) activity is required for lipid accumulation in 3T3-L1 adipocytes. The present study characterized the role of endogenous Bmp activity in preadipocytes. Endogenous Bmp activity was monitored by analyzing the level of phosphorylation of Smad1/5/8, downstream molecules in the Bmp pathway. Higher levels of phosphorylated Smad1/5/8 were detected in adipogenic cells but not in non-adipogenic cells prior to differentiation induction. The inhibition of the Bmp pathway during this period decreased the expression of Pparγ2 and C/ebpα, which are transcription factors responsible for adipocyte differentiation. The expression of these transcription factors were also down-regulated by Bmp4 knockdown. In addition, endogenous Bmp4 was required for the repression of Intrleukin-11 expression. Endogenous Bmp4 in preadipocytes is indispensable for the onset of the adipogenic program, and may help to maintain the preadipocytic state during adipocyte differentiation. |
著作権等: | © 2013 Elsevier Ltd. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/178733 |
DOI(出版社版): | 10.1016/j.cyto.2013.07.011 |
PubMed ID: | 23911203 |
出現コレクション: | 学術雑誌掲載論文等 |
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