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dc.contributor.author | Suenaga, Masashi | en |
dc.contributor.author | Kurosawa, Norio | en |
dc.contributor.author | Asano, Hiroki | en |
dc.contributor.author | Kanamori, Yohei | en |
dc.contributor.author | Umemoto, Takenao | en |
dc.contributor.author | Yoshida, Hirofumi | en |
dc.contributor.author | Murakami, Masaru | en |
dc.contributor.author | Kawachi, Hiroyuki | en |
dc.contributor.author | Matsui, Tohru | en |
dc.contributor.author | Funaba, Masayuki | en |
dc.contributor.alternative | 舟場, 正幸 | ja |
dc.date.accessioned | 2013-09-19T07:08:47Z | - |
dc.date.available | 2013-09-19T07:08:47Z | - |
dc.date.issued | 2013-10 | - |
dc.identifier.issn | 1043-4666 | - |
dc.identifier.uri | http://hdl.handle.net/2433/178733 | - |
dc.description.abstract | We previously revealed that endogenous bone morphogenetic protein (Bmp) activity is required for lipid accumulation in 3T3-L1 adipocytes. The present study characterized the role of endogenous Bmp activity in preadipocytes. Endogenous Bmp activity was monitored by analyzing the level of phosphorylation of Smad1/5/8, downstream molecules in the Bmp pathway. Higher levels of phosphorylated Smad1/5/8 were detected in adipogenic cells but not in non-adipogenic cells prior to differentiation induction. The inhibition of the Bmp pathway during this period decreased the expression of Pparγ2 and C/ebpα, which are transcription factors responsible for adipocyte differentiation. The expression of these transcription factors were also down-regulated by Bmp4 knockdown. In addition, endogenous Bmp4 was required for the repression of Intrleukin-11 expression. Endogenous Bmp4 in preadipocytes is indispensable for the onset of the adipogenic program, and may help to maintain the preadipocytic state during adipocyte differentiation. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier Ltd. | en |
dc.rights | © 2013 Elsevier Ltd. | en |
dc.rights | This is not the published version. Please cite only the published version. | en |
dc.rights | この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | ja |
dc.subject | Bmp4 | en |
dc.subject | Adipocyte differentiation | en |
dc.subject | Preadipocytes | en |
dc.subject | Interleukin-11 | en |
dc.title | Bmp4 expressed in preadipocytes is required for the onset of adipocyte differentiation | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.ncid | AA10794201 | - |
dc.identifier.jtitle | Cytokine | en |
dc.identifier.volume | 64 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 138 | - |
dc.identifier.epage | 145 | - |
dc.relation.doi | 10.1016/j.cyto.2013.07.011 | - |
dc.textversion | author | - |
dc.identifier.pmid | 23911203 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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