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タイトル: Metabolic engineering for the production of polyunsaturated fatty acids by oleaginous fungus Mortierella alpina 1S-4.
著者: Sakuradani, Eiji
Ando, Akinori  kyouindb  KAKEN_id
Shimizu, Sakayu
Ogawa, Jun  kyouindb  KAKEN_id
著者名の別形: 櫻谷, 英治
キーワード: Mortierella alpina
Polyunsaturated fatty acid
Arachidonic acid (AA)
Eicosapentaenoic acid (EPA)
Molecular breeding
Fatty acid desaturase
発行日: Oct-2013
出版者: Elsevier B.V.
誌名: Journal of bioscience and bioengineering
巻: 116
号: 4
開始ページ: 417
終了ページ: 422
抄録: Researches related with the application of functional lipids such as polyunsaturated fatty acids (PUFAs) have been conducted in various fields with a view to health and dietary requirements. Novel rich sources other than known natural sources such as plant seeds and fish oils are required for increasing demands of PUFAs. The filamentous fungus Mortierella alpina 1S-4 produces triacylglycerols rich in arachidonic acid, i.e., ones reaching 20 g/l in concentration and containing 30-70% arachidonic acid as total fatty acids. Various mutants derived from M. alpina 1S-4 have led to the production of oils containing various PUFAs. Molecular breeding of M. alpina strains by means of manipulation of the genes involved in PUFA biosynthesis facilitates improvement of PUFA productivity and elucidation of the functions of their enzymes. This review describes practical PUFA production through mutant breeding, functional analyses of the genes of the enzymes involved in PUFA biosynthesis, and recent advances in unique PUFA production through molecular breeding.
著作権等: © 2013 The Society for Biotechnology, Japan. Published by Elsevier B.V.
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
URI: http://hdl.handle.net/2433/178746
DOI(出版社版): 10.1016/j.jbiosc.2013.04.008
PubMed ID: 23648102
出現コレクション:学術雑誌掲載論文等

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