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Title: Chemical and genomic evolution of enzyme-catalyzed reaction networks.
Authors: Kanehisa, Minoru
Author's alias: 金久, 實
Keywords: Evolution of metabolism
Metabolic pathway
Enzyme cluster
Reaction module
KEGG database
Issue Date: 2-Sep-2013
Publisher: Elsevier B.V.
Journal title: FEBS letters
Volume: 587
Issue: 17
Start page: 2731
End page: 2737
Abstract: There is a tendency that a unit of enzyme genes in an operon-like structure in the prokaryotic genome encodes enzymes that catalyze a series of consecutive reactions in a metabolic pathway. Our recent analysis shows that this and other genomic units correspond to chemical units reflecting chemical logic of organic reactions. From all known metabolic pathways in the KEGG database we identified chemical units, called reaction modules, as the conserved sequences of chemical structure transformation patterns of small molecules. The extracted patterns suggest co-evolution of genomic units and chemical units. While the core of the metabolic network may have evolved with mechanisms involving individual enzymes and reactions, its extension may have been driven by modular units of enzymes and reactions.
Rights: © 2013 Federation of European Biochemical Societies. Published by Elsevier B.V.
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
URI: http://hdl.handle.net/2433/178762
DOI(Published Version): 10.1016/j.febslet.2013.06.026
PubMed ID: 23816707
Appears in Collections:Journal Articles

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