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Title: Efficient in vivo depletion of CD8(+) T lymphocytes in common marmosets by novel CD8 monoclonal antibody administration.
Authors: Yoshida, Tomoyuki
Suzuki, Saori
Iwasaki, Yuki
Kaneko, Akihisa
Saito, Akatsuki
Enomoto, Yuki
Higashino, Atsunori  kyouindb  KAKEN_id  orcid (unconfirmed)
Watanabe, Akino
Suzuki, Juri  kyouindb  KAKEN_id
Inoue, Kenichi  kyouindb  KAKEN_id  orcid (unconfirmed)
Kuroda, Teiko
Takada, Masahiko  kyouindb  KAKEN_id
Ito, Ryoji
Ito, Mamoru
Akari, Hirofumi  kyouindb  KAKEN_id  orcid (unconfirmed)
Author's alias: 吉田, 友教
明里, 宏文
Keywords: Monoclonal antibody
CD8 T lymphocyte
Common marmoset
n vivo depletion
Issue Date: Jul-2013
Publisher: Elsevier B.V.
Journal title: Immunology letters
Volume: 154
Issue: 1-2
Start page: 12
End page: 17
Abstract: In order to directly demonstrate the roles of CD8(+) T lymphocytes in non-human primates, in vivo depletion of the CD8(+) T cells by administration of a CD8-specific monoclonal antibody (mAb) is one of the crucial techniques. Recently, the common marmoset (Callithrix jacchus), which is classified as a New World monkey, has been shown useful as an experimental animal model for various human diseases such as multiple sclerosis, Parkinson's disease and a number of infectious diseases. Here we show that an anti-marmoset CD8 mAb 6F10, which we have recently established, efficiently depletes the marmoset CD8(+) T lymphocytes in vivo, i.e., the administration of 6F10 induces drastic and specific reduction in the ratio of the CD8(+) T cell subset for at least three weeks or longer. Our finding will help understand the pivotal role of CD8(+) T cells in vivo in the control of human diseases.
Rights: © 2013 Elsevier B.V.
この論文は著者最終稿です。内容が印刷版と異なることがありますので、引用の際には出版社版をご確認ご利用ください。This is the Accepted Author Manuscript. Please cite only the published version.
DOI(Published Version): 10.1016/j.imlet.2013.08.005
PubMed ID: 23969290
Appears in Collections:Journal Articles

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