|Title:||Efficient in vivo depletion of CD8(+) T lymphocytes in common marmosets by novel CD8 monoclonal antibody administration.|
Higashino, Atsunori https://orcid.org/0000-0002-0817-967X (unconfirmed)
Inoue, Kenichi https://orcid.org/0000-0002-5683-5280 (unconfirmed)
Akari, Hirofumi https://orcid.org/0000-0003-2166-6015 (unconfirmed)
|Author's alias:||吉田, 友教|
CD8 T lymphocyte
n vivo depletion
|Journal title:||Immunology letters|
|Abstract:||In order to directly demonstrate the roles of CD8(+) T lymphocytes in non-human primates, in vivo depletion of the CD8(+) T cells by administration of a CD8-specific monoclonal antibody (mAb) is one of the crucial techniques. Recently, the common marmoset (Callithrix jacchus), which is classified as a New World monkey, has been shown useful as an experimental animal model for various human diseases such as multiple sclerosis, Parkinson's disease and a number of infectious diseases. Here we show that an anti-marmoset CD8 mAb 6F10, which we have recently established, efficiently depletes the marmoset CD8(+) T lymphocytes in vivo, i.e., the administration of 6F10 induces drastic and specific reduction in the ratio of the CD8(+) T cell subset for at least three weeks or longer. Our finding will help understand the pivotal role of CD8(+) T cells in vivo in the control of human diseases.|
|Rights:||© 2013 Elsevier B.V.|
この論文は著者最終稿です。内容が印刷版と異なることがありますので、引用の際には出版社版をご確認ご利用ください。This is the Accepted Author Manuscript. Please cite only the published version.
|Appears in Collections:||Journal Articles|
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