ダウンロード数: 564
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
pnas.1312937110.pdf | 3.29 MB | Adobe PDF | 見る/開く |
タイトル: | Polyunsaturated fatty acid saturation by gut lactic acid bacteria affecting host lipid composition. |
著者: | Kishino, Shigenobu https://orcid.org/0000-0002-4587-2422 (unconfirmed) Takeuchi, Michiki Park, Si-Bum Hirata, Akiko Kitamura, Nahoko Kunisawa, Jun Kiyono, Hiroshi Iwamoto, Ryo Isobe, Yosuke Arita, Makoto Arai, Hiroyuki Ueda, Kazumitsu https://orcid.org/0000-0003-2980-6078 (unconfirmed) Shima, Jun Takahashi, Satomi Yokozeki, Kenzo Shimizu, Sakayu Ogawa, Jun https://orcid.org/0000-0003-2741-621X (unconfirmed) |
著者名の別形: | 岸野, 重信 清野, 宏 國澤, 純 有田, 誠 新井, 洋由 植田, 和光 島, 純 清水, 昌 小川, 順 |
キーワード: | biohydrogenation hydratase fatty acid isomerase conjugated linoleic acid lipid nutrition |
発行日: | 14-Oct-2013 |
出版者: | National Academy of Sciences |
誌名: | Proceedings of the National Academy of Sciences of the United States of America |
巻: | 110 |
号: | 44 |
開始ページ: | 17808 |
終了ページ: | 17813 |
抄録: | In the representative gut bacterium Lactobacillus plantarum, we identified genes encoding the enzymes involved in a saturation metabolism of polyunsaturated fatty acids and revealed in detail the metabolic pathway that generates hydroxy fatty acids, oxo fatty acids, conjugated fatty acids, and partially saturated trans-fatty acids as intermediates. Furthermore, we observed these intermediates, especially hydroxy fatty acids, in host organs. Levels of hydroxy fatty acids were much higher in specific pathogen-free mice than in germ-free mice, indicating that these fatty acids are generated through polyunsaturated fatty acids metabolism of gastrointestinal microorganisms. These findings suggested that lipid metabolism by gastrointestinal microbes affects the health of the host by modifying fatty acid composition. |
記述: | 腸内細菌の脂肪酸代謝を解明 -腸内細菌と食事のバランスによる生活習慣病予防への新たな視点-. 京都大学プレスリリース. 2013-10-15. |
著作権等: | © 2013 National Academy of Sciences. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 This is not the published version. Please cite only the published version. |
URI: | http://hdl.handle.net/2433/179285 |
DOI(出版社版): | 10.1073/pnas.1312937110 |
PubMed ID: | 24127592 |
関連リンク: | https://www.kyoto-u.ac.jp/static/ja/news_data/h/h1/news6/2013_1/131004_2.htm |
出現コレクション: | 学術雑誌掲載論文等 |
このリポジトリに保管されているアイテムはすべて著作権により保護されています。