このアイテムのアクセス数: 181

このアイテムのファイル:
ファイル 記述 サイズフォーマット 
bpb.b13-00250.pdf1.6 MBAdobe PDF見る/開く
タイトル: Sedative Effects of Inhaled Benzylacetone and Structural Features Contributing to Its Activity
著者: Miyoshi, Takashi
Ito, Michiho  kyouindb  KAKEN_id
Kitayama, Takashi
Isomori, Sachiko
Yamashita, Fumiyoshi  kyouindb  KAKEN_id
著者名の別形: 伊藤, 美千穂
キーワード: benzylacetone
sedative effect
inhalation
structure–activity relationship
fuzzy adaptive least square
発行日: Sep-2013
出版者: The Pharmaceutical Society of Japan
誌名: Biological and Pharmaceutical Bulletin
巻: 36
号: 9
開始ページ: 1474
終了ページ: 1481
抄録: Benzylacetone is released by heated agarwood, when inhaled it has a potent effect on reducing the locomotor activity of mice. This study investigated the relationships between the sedative activities of benzylacetone and its derivatives as well as the chemical structures of these compounds by comparing their activities in mice treated with a series of compounds. It was demonstrated that benzylacetone-like compounds had sedative activities and their intensities varied depending on the functional group in the carbon chain, the substituent in the benzene ring, and their combinations. A quantitative structure–activity relationship study was carried out using a series of 17 benzylacetone derivatives to determine the structural features with significant for the sedative activity.
著作権等: © 2013 The Pharmaceutical Society of Japan
URI: http://hdl.handle.net/2433/179289
DOI(出版社版): 10.1248/bpb.b13-00250
出現コレクション:学術雑誌掲載論文等

アイテムの詳細レコードを表示する

Export to RefWorks


出力フォーマット 


このリポジトリに保管されているアイテムはすべて著作権により保護されています。