ダウンロード数: 326
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
bpb.b13-00250.pdf | 1.6 MB | Adobe PDF | 見る/開く |
タイトル: | Sedative Effects of Inhaled Benzylacetone and Structural Features Contributing to Its Activity |
著者: | Miyoshi, Takashi Ito, Michiho https://orcid.org/0000-0001-9821-0628 (unconfirmed) Kitayama, Takashi Isomori, Sachiko Yamashita, Fumiyoshi https://orcid.org/0000-0002-3503-8696 (unconfirmed) |
著者名の別形: | 伊藤, 美千穂 |
キーワード: | benzylacetone sedative effect inhalation structure–activity relationship fuzzy adaptive least square |
発行日: | Sep-2013 |
出版者: | Pharmaceutical Society of Japan |
誌名: | Biological and Pharmaceutical Bulletin |
巻: | 36 |
号: | 9 |
開始ページ: | 1474 |
終了ページ: | 1481 |
抄録: | Benzylacetone is released by heated agarwood, when inhaled it has a potent effect on reducing the locomotor activity of mice. This study investigated the relationships between the sedative activities of benzylacetone and its derivatives as well as the chemical structures of these compounds by comparing their activities in mice treated with a series of compounds. It was demonstrated that benzylacetone-like compounds had sedative activities and their intensities varied depending on the functional group in the carbon chain, the substituent in the benzene ring, and their combinations. A quantitative structure–activity relationship study was carried out using a series of 17 benzylacetone derivatives to determine the structural features with significant for the sedative activity. |
著作権等: | © 2013 The Pharmaceutical Society of Japan |
URI: | http://hdl.handle.net/2433/179289 |
DOI(出版社版): | 10.1248/bpb.b13-00250 |
PubMed ID: | 23995659 |
出現コレクション: | 学術雑誌掲載論文等 |
このリポジトリに保管されているアイテムはすべて著作権により保護されています。