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Title: Sedative Effects of Inhaled Benzylacetone and Structural Features Contributing to Its Activity
Authors: Miyoshi, Takashi
Ito, Michiho  kyouindb  KAKEN_id  orcid (unconfirmed)
Kitayama, Takashi
Isomori, Sachiko
Yamashita, Fumiyoshi  kyouindb  KAKEN_id  orcid (unconfirmed)
Author's alias: 伊藤, 美千穂
Keywords: benzylacetone
sedative effect
structure–activity relationship
fuzzy adaptive least square
Issue Date: Sep-2013
Publisher: The Pharmaceutical Society of Japan
Journal title: Biological and Pharmaceutical Bulletin
Volume: 36
Issue: 9
Start page: 1474
End page: 1481
Abstract: Benzylacetone is released by heated agarwood, when inhaled it has a potent effect on reducing the locomotor activity of mice. This study investigated the relationships between the sedative activities of benzylacetone and its derivatives as well as the chemical structures of these compounds by comparing their activities in mice treated with a series of compounds. It was demonstrated that benzylacetone-like compounds had sedative activities and their intensities varied depending on the functional group in the carbon chain, the substituent in the benzene ring, and their combinations. A quantitative structure–activity relationship study was carried out using a series of 17 benzylacetone derivatives to determine the structural features with significant for the sedative activity.
Rights: © 2013 The Pharmaceutical Society of Japan
DOI(Published Version): 10.1248/bpb.b13-00250
Appears in Collections:Journal Articles

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