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Title: Sensory-Neuron Subtype-Specific Transcriptional Programs Controlling Dendrite Morphogenesis: Genome-wide Analysis of Abrupt and Knot/Collier
Authors: Hattori, Yukako  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0001-5977-8501 (unconfirmed)
Usui, Tadao  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-0507-1495 (unconfirmed)
Satoh, Daisuke
Moriyama, Sanefumi
Shimono, Kohei
Itoh, Takehiko
Shirahige, Katsuhiko
Uemura, Tadashi  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0001-7204-3606 (unconfirmed)
Author's alias: 服部, 佑佳子
碓井, 理夫
佐藤, 大祐
森山, 翔文
下野, 耕平
伊藤, 武彦
白髭, 克彦
上村, 匡
Issue Date: 9-Dec-2013
Publisher: Elsevier B.V.
Journal title: Developmental Cell
Volume: 27
Issue: 5
Start page: 530
End page: 544
Abstract: The transcription factors Abrupt (Ab) and Knot (Kn) act as selectors of distinct dendritic arbor morphologies in two classes of Drosophila sensory neurons, termed class I and class IV, respectively. We performed binding-site mapping and transcriptional profiling of isolated these neurons. Their profiles were similarly enriched in cell-type-specific enhancers of genes implicated in neural development. We identified a total of 429 target genes, of which 56 were common to Ab and Kn; these targets included genes necessary to shape dendritic arbors in either or both of the two sensory subtypes. Furthermore, a common target gene, encoding the cell adhesion molecule Ten-m, was expressed more strongly in class I than IV, and this differential was critical to the class-selective directional control of dendritic branch sprouting or extension. Our analyses illustrate how differentiating neurons employ distinct and shared repertoires of gene expression to produce class-selective morphological traits.
Description: 神経細胞の個性を生み出すしくみの解明 -サブタイプ特異的な形づくりの遺伝子プログラム-. 京都大学プレスリリース. 2013-11-28.
Rights: © 2013 Elsevier B.V.
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
URI: http://hdl.handle.net/2433/179534
DOI(Published Version): 10.1016/j.devcel.2013.10.024
Related Link: https://www.kyoto-u.ac.jp/static/ja/news_data/h/h1/news6/2013_1/131128_1.htm
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