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j.coviro.2013.08.010.pdf | 859.47 kB | Adobe PDF | 見る/開く |
タイトル: | Human T-cell leukemia virus type 1: replication, proliferation and propagation by Tax and HTLV-1 bZIP factor. |
著者: | Matsuoka, Masao Yasunaga, Jun-Ichirou https://orcid.org/0000-0002-7939-2080 (unconfirmed) |
著者名の別形: | 松岡, 雅雄 |
発行日: | Dec-2013 |
出版者: | Elsevier B.V. |
誌名: | Current opinion in virology |
巻: | 3 |
号: | 6 |
開始ページ: | 684 |
終了ページ: | 691 |
抄録: | Human T-cell leukemia virus type 1 (HTLV-1) spreads primarily by cell-to-cell transmission. Therefore, HTLV-1 promotes the proliferation of infected cells to facilitate transmission. In HTLV-1 infected individuals, the provirus is present mainly in effector/memory T cells and Foxp3+ T cells. Recent study suggests that this immunophenotype is acquired by infected cells through the function of HTLV-1 bZIP factor (HBZ). Tax, which is encoded by the plus strand, is crucial for viral replication and de novo infection, while HBZ, encoded by the minus strand, is important for proliferation of infected cells. Importantly, HBZ and Tax have opposing functions in most transcription pathways. HBZ and Tax cooperate in elaborate ways to permit viral replication, proliferation of infected cells and propagation of the virus. |
著作権等: | © 2013 Elsevier B.V. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/180094 |
DOI(出版社版): | 10.1016/j.coviro.2013.08.010 |
PubMed ID: | 24060211 |
出現コレクション: | 学術雑誌掲載論文等 |
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