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タイトル: | Critical roles of nardilysin in the maintenance of body temperature homoeostasis. |
著者: | Hiraoka, Yoshinori Matsuoka, Tatsuhiko Ohno, Mikiko Nakamura, Kazuhiro Saijo, Sayaka Matsumura, Shigenobu Nishi, Kiyoto Sakamoto, Jiro Chen, Po-Min Inoue, Kazuo https://orcid.org/0000-0001-7003-8635 (unconfirmed) Fushiki, Tohru Kita, Toru Kimura, Takeshi Nishi, Eiichiro |
著者名の別形: | 西, 英一郎 |
キーワード: | Biological sciences Medical research |
発行日: | 4-Feb-2014 |
出版者: | Nature Publishing Group |
誌名: | Nature communications |
巻: | 5 |
論文番号: | 3224 |
抄録: | Body temperature homoeostasis in mammals is governed centrally through the regulation of shivering and non-shivering thermogenesis and cutaneous vasomotion. Non-shivering thermogenesis in brown adipose tissue (BAT) is mediated by sympathetic activation, followed by PGC-1α induction, which drives UCP1. Here we identify nardilysin (Nrd1 and NRDc) as a critical regulator of body temperature homoeostasis. Nrd1(-/-) mice show increased energy expenditure owing to enhanced BAT thermogenesis and hyperactivity. Despite these findings, Nrd1(-/-) mice show hypothermia and cold intolerance that are attributed to the lowered set point of body temperature, poor insulation and impaired cold-induced thermogenesis. Induction of β3-adrenergic receptor, PGC-1α and UCP1 in response to cold is severely impaired in the absence of NRDc. At the molecular level, NRDc and PGC-1α interact and co-localize at the UCP1 enhancer, where NRDc represses PGC-1α activity. These findings reveal a novel nuclear function of NRDc and provide important insights into the mechanism of thermoregulation. |
記述: | 「体温恒常性維持のメカニズムの解明」に成功. 京都大学プレスリリース. 2014-02-04. |
著作権等: | © 2014 Macmillan Publishers Limited. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/ |
URI: | http://hdl.handle.net/2433/180643 |
DOI(出版社版): | 10.1038/ncomms4224 |
PubMed ID: | 24492630 |
関連リンク: | https://www.kyoto-u.ac.jp/static/ja/news_data/h/h1/news6/2013_1/140204_1.htm |
出現コレクション: | 学術雑誌掲載論文等 |
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