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Title: Small Animal Imaging with Hyperpolarized 129Xe Magnetic Resonance
Authors: IMAI, Hirohiko  kyouindb  KAKEN_id
KIMURA, Atsuomi
Author's alias: 今井, 宏彦
Keywords: Hyperpolarization
lung MRI
pulmonary function
small animal imaging
Issue Date: 10-Jan-2014
Publisher: Japan Society for Analytical Chemistry
Journal title: Analytical Sciences
Volume: 30
Issue: 1
Start page: 157
End page: 166
Abstract: High-sensitivity nuclear magnetic resonance (NMR) of gaseous atoms realized by using a hyperpolarization technique is an attractive research tool used in a wide range of areas, such as physics, chemistry, material science and biomedical imaging. One of the most promising applications of this technology is the use as a noninvasive diagnostic tool for pulmonary diseases, where hyperpolarized (HP) noble gases, 3He and 129Xe, play a role as gaseous (i.e. inhalable) contrast agents of magnetic resonance imaging (MRI). During the last two decades, lung MRI with HP gases has become widely applicable from mouse to human. In this review we present a brief overview of recent progress made by our group in the development of HP 129Xe MR measurements, while focusing on the methodology for probing pulmonary dysfunctions in mice.
Rights: © 2014 by The Japan Society for Analytical Chemistry.
DOI(Published Version): 10.2116/analsci.30.157
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