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Title: チベット高地における老化と酸化ストレス
Other Titles: Senescence and Oxidative Stress at High Altitude
Authors: 坂本, 龍太  kyouindb  KAKEN_id
松林, 公蔵  KAKEN_name
木村, 友美  KAKEN_name
石根, 昌幸  KAKEN_name
和田, 泰三  KAKEN_name
Wang, Hongxing
Dai, Qingxiang
Yang, Airong
Qiao, Haisheng
Gao, Jidong
Li, Zhanquan
Zhang, Yongshou
Ge, Ri Li
奥宮, 清人  KAKEN_name
Author's alias: Sakamoto, Ryota
Matsubayashi, Kozo
Kimura, Yumi
Ishine, Masayuki
Wada, Taizo
Wang, Hongxing
Dai, Qingxiang
Yang, Airong
Qiao, Haisheng
Gao, Jidong
Li, Zhanquan
Zhang, Yongshou
Ge, Ri Li
Okumiya, Kiyohito
Keywords: high-altitude
oxidative stress
senescence
reactive oxygen species
Issue Date: 1-May-2010
Publisher: 京都大学ヒマラヤ研究会・人間文化研究機構 総合地球環境学研究所「高所プロジェクト」
Journal title: ヒマラヤ学誌 : Himalayan Study Monographs
Volume: 11
Start page: 21
End page: 28
Abstract: Oxidative stress is hypothesized to be one of the main causes of senescence. Although there are several environmental factors which may contribute to the oxidative stress at high altitude, little is known about the association between oxidative stress and senescence in the community-dwelling elderly at high altitude. We examined reactive oxygen species (ROS) and comprehensive geriatric functions among community-dwelling elderly subjects aged 60 years or more in Tibetan plateau. As a marker of ROS, the levels of reactive oxygen metabolites (ROM) were measured using the d-ROM test (Diacron, Parma, Italy). Stepwise multiple regression analysis showed that the Tibetan, female, hemoglobin and oxygen saturation were independent associated factors of increasing d-ROM level. The high levels of ROM were significantly associated with dependence of basic ADL after adjustment for age, sex and ethnicity. Further studies are needed to show the association among adaptation pattern to high altitude, oxidative stress and senescence.
DOI: 10.14989/HSM.11.21
URI: http://hdl.handle.net/2433/186071
Appears in Collections:第11号

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