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j.ejps.2014.03.002.pdf716.79 kBAdobe PDF見る/開く
タイトル: DNA nanotechnology-based development of delivery systems for bioactive compounds.
著者: Mohri, Kohta
Nishikawa, Makiya
Takahashi, Yuki  kyouindb  KAKEN_id
Takakura, Yoshinobu  kyouindb  KAKEN_id
著者名の別形: 高橋, 有己
高倉, 喜信
キーワード: DNA nanotechnology
Drug delivery system
CpG DNA
Immune response
発行日: 16-Jul-2014
出版者: Elsevier B.V.
誌名: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
巻: 58
開始ページ: 26
終了ページ: 33
抄録: Nucleic acids, DNA and RNA, not only allow transfer and replication of densely coded genetic information, but also act as danger signals triggering innate immune response. Recent progress in the design and construction of nano-sized structures using DNA has opened a new field of nanotechnology. The unique properties of nano-sized DNA constructs can be exploited to develop programmable materials for efficient delivery of bioactive compounds. In this review, recent advances in DNA nanotechnology and its applications as delivery systems are summarized. In particular, we focus on the delivery of DNA containing unmethylated cytosine-phosphate-guanine (CpG) dinucleotide, or CpG motif, to immune cells expressing Toll-like receptor 9. Recent studies have shown that precisely designed DNA constructs, such as multi-branched DNA, polyhedral DNA, and DNA origami, can be used to enhance the biological activity of CpG DNA.
著作権等: © 2014 Elsevier B.V.
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
URI: http://hdl.handle.net/2433/187365
DOI(出版社版): 10.1016/j.ejps.2014.03.002
PubMed ID: 24694593
出現コレクション:学術雑誌掲載論文等

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